纳米级羟基磷灰石梯度涂层植入体骨结合的研究  

Experimental study on the osteointegration of nanophase hydroxyapatite biograde-coated implants

作　　者：王毅[1] 谭延斌[1] 杨庆铭[1] 邓廉夫[1] 曾绍先[2] 

机构地区：[1]上海市伤骨科研究所上海第二医科大学附属瑞金医院骨科,200025 [2]中国科学院上海硅酸盐研究所

出　　处：《中华外科杂志》2005年第20期1336-1339,共4页Chinese Journal of Surgery

基　　金：上海市纳米专项资助项目(0144nm064)

摘　　要：目的研究纳米级羟基磷灰石梯度涂层植入体的骨结合情况。方法在Beagle犬股骨髁植入纳米级羟基磷灰石梯度涂层栓、普通级羟基磷灰石栓和钛合金(Ti-6AL-4V)栓,4、8和12周比较植入体-骨界面的组织学、骨动力学参数并进行电镜观察。结果纳米级羟基磷灰石梯度涂层组的降解速度慢于普通级羟基磷灰石组,骨动力学参数和成骨细胞形态均优于对照组。结论纳米级羟基磷灰石梯度涂层植入体优于普通级羟基磷灰石涂层植入体。Objective To study the osteointegration of the nanophase hydroxyapatite biogradecoated implants and host bone. Methods Nanophase hydroxyapatite biograde-coated implants, hydroxyapatite biograde-coated implants and noncoated Ti-6Al-4V implants were inserted into both femoral of Beagle canines the tissue response, dynamic osteogensis and SEM were studied at 4, 8 and 12 weeks. Results The degradation of nanophase hydroxyapatite was slower than hydroxyapatite, dynamic osteogensis and the form of osteoblast were better than the control groups. Conclusion The biological reaction of Nanophase hydroxyapatite biograde-coated implants is better than hydroxyapatite coated implant.

关 键 词：羟基磷灰石 成骨细胞 纳米级 

分 类 号：R318.08[医药卫生—生物医学工程]