神经生长因子（NGF）促进挤压伤坐骨神经再生  

EnhancementofRegenerationoftheCrushedRatSciaticNerveUsingNerveGrowthFactor(NGF)

作　　者：王民生[1] 陈中伟[1] 张光健[1] 陈峥嵘[1] 

机构地区：[1]上海医科大学中山医院骨科

出　　处：《中华骨科杂志》1996年第3期166-168,共3页Chinese Journal of Orthopaedics

摘　　要：作者就神经生长因子（ＮＧＦ）对挤压伤坐骨神经再生和作用进行了研究．３０只大鼠分为６组，每组各５只，双侧１０条坐骨神经．其中３组为对照组，３组为ＮＧＦ治疗组，观察期分别为１２、２８和５６天．结果显示ＮＧＦ治疗可使神经肌肉动作电位出现提早，运动神经传导速度加快，再生有髓神经纤维直径增粗及早期再生有髓神经纤维数量增加，表明ＮＧＦ可促进挤压伤坐骨神经再生．ThirtymaleWistarratsweredividedinto6groupseachcontaining5animals.Thebilat-eralsciaticnerveswereusedintheexperimentalstudy.Therewere3controlgroupsand3nervegrowthfactor(NGF)-treatedgroups.Afterthecrushingofthespecimens,2.1μlnormalsalineor2.1μlNGF(1μg)wereinjectedintothecrushedsitesofthecontrolsandtheexperimentalanimalsandfolow-upobservationsweredoneatthe12th,28th,and56thdaysrespectively.Atthe12thday,evokedmuscleac-tionpotential(MAP)waselicitedin50%oftheNGF-treatedspecimens,andinnoneofthecontrolgroup(P<0.05).ThemotornerveconductivevelocityoftheNGF-treatedgroupat28thand56thdayswassignificantlyfasterthanthatofthecontrolgroup.Morphometricaly,moreregeneratedmyelinatedfibers(RMF)withlargerdiametersweredemonstratedintheNGF-treatedgroupsatthe12,28and56days.TheseresultsindicatedthattopicaluseofNGF-promotednerveregenerationandenhancedthematurationofmyelinatedfibersofthecrushedsciaticnervesoftherats.

关 键 词：神经生长因子 神经挤压伤 神经再生 

分 类 号：R642.05[医药卫生—外科学]