极大螺旋藻胞内多糖IPSⅡA逆转化疗模型小鼠免疫功能的研究  

Chemo-protective effects of intracellular polysaccharide of Spirulina maxima on immune system of mice

作　　者：朱劲华[1] 张威[1] 王敏[2] 李朝军[2] 张成武[2] 

机构地区：[1]江苏职工医科大学,江苏南京210029 [2]南京师范大学生命科学学院,江苏南京210097

出　　处：《海洋科学》2005年第11期18-21,共4页Marine Sciences

摘　　要：研究了极大螺旋藻(Spirulinamaxima)胞内多糖IPSⅡA对化疗模型小鼠免疫功能的影响。通过注射环磷酰胺构建化疗小鼠模型,再分别注射不同剂量(0.5、1、2μg/g)的IPSⅡA,14d后进行外周血白细胞计数、免疫器官称质量并且应用炭粒廓清法和溶血素测定法测定单核细胞吞噬功能和B淋巴细胞的体液免疫功能。结果发现IPSⅡA能显著改善环磷酰胺所致白细胞减少、胸脾指数降低,还能使单核细胞吞噬功能、B淋巴细胞的体液免疫功能得以恢复和提高,并且存在剂量累积效应。可见IPSⅡA能显著逆转化疗模型小鼠的免疫功能,具有成为癌症化疗辅助药物的潜能。The effect of intracellular polysaccharide of Spirulina maxima（IPS Ⅱ A） on immune system of mice treated by injection ofcyclophosphamide（CTX） was observed. CTX was used to induce immune system low, and the experimental animals were injected with different doses oflPS for 14 d administration, the white cells were measured, the immune organs were weighed, and the functions of monocyte swallowing and the functions of B lymphocyte were inspected. IPS Ⅱ A obviously improves the functions of immune system of mice treated with CTX, and the results showed dose-dependent patterns. IPS Ⅱ A possesses chemo-protective capability ,and may be a potential adjunct to cancer therapy.

关 键 词：极大螺旋藻(Spirulina maxima) 胞内多糖 化疗 免疫激活 小鼠模型 

分 类 号：R93[医药卫生—生药学]