类风湿关节炎患者抗环瓜氨酸肽抗体的测定及临床意义  

Diagnostic value of anti-cyclic citrullinated peptide antibody assay for rheumatoid arthritis

作　　者：韩玉祥[1] 邵福灵[1] 刘凤珍[1] 靳洪涛[1] 刘晓雷[1] 

机构地区：[1]河北医科大学第二医院免疫风湿科,河北石家庄050000

出　　处：《临床荟萃》2005年第22期1276-1278,共3页Clinical Focus

摘　　要：目的检测抗环瓜氨酸肽抗体(抗CCP抗体)在类风湿关节炎(RA)中的阳性率及在RA诊断中的意义。方法用酶联免疫吸附测定(ELISA)方法检测60例RA,30例非RA的其他风湿病患者,其中包括系统性红斑狼疮(SLE),原发干燥综合征(PSS),强直性脊柱炎(AS),关节炎(OA)以及30例健康对照组中的抗CCP抗体。结果抗CCP抗体对RA的敏感性为76.67%,特异性为96.67%,阳性预测值为95.83%,阴性预测值为80.56%;30例早期RA患者中25例抗CCP抗体阳性(83.33%)。抗CCP抗体与抗角蛋白抗体(AKA)(r=0.56,P<0.05)及类风湿因子(RF)(r=0.36,P<0.05)均有相关性。结论抗CCP抗体能用于RA,特别是早期RA的诊断。Objective To evaluate the diagnostic and analytical performances of a new commercial enzyme-linked immunosorbent assay（ELISA） for the detection of anti-cyclic citrullinated peptides（anti-CCP） antibodies in rheumatoid arthritis （RA）,especially in early RA. Methods The anti-CCP was detected in 60 RA patients,30 non-RA patients （other connective tissue disease except RA） and 30 healthy controls. Results The sensitivity and specificity of anti- CCP for RA were 76.67% and 96.62M ,positive predictive value （PPV） was 95.83% ,negative predictive value （NPV） was 80.56 %. In the early RA cohort of 30 patients, 25/30 （83.33 % ） were anti-CCP positive. Anti-CCP was positive associated with antikeratin antihady （ r =0.56, P %0.05） ,rheumatoid factor（ r =0.36, P %0.05）. Conclusion AntiCCP can be used in RA,especially in the early RA.

关 键 词：关节炎 类风湿 抗体生成 酶联免疫吸附测定 类风湿因子 

分 类 号：R593.22[医药卫生—内科学]