反式-对戊基环己基苄基甲酮的合成  

Synthesis of trans-p-pentylcyclohexylbenzylketone

作　　者：章于川[1] 沈金平[1] 杭德余[1] 孙红杰[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《安徽大学学报（自然科学版）》2005年第6期65-67,共3页Journal of Anhui University(Natural Science Edition)

基　　金：安徽省"十五"科技攻关项目基金资助项目(200183)

摘　　要：以反式-对戊基环己基甲酸为原料,经酰氯化,氨解,脱水,G rignard反应四步合成乙烷类液晶中间体反式-对戊基环己基苄基甲酮.对G rignard反应合成条件进行了研究,获得了优化反应条件是:采用四氢呋喃和甲苯混合溶剂,n(C6H5CH2MgC l)∶n(C5H11C6H10CN)=1∶1.5,反应10h,总收率为41.5%.目标产物经IR和1HNMR确证其结构.Trans-p- Pentylcyclohexylbenzylketone is an intermediate to synthesize ethane＇s liquid crystal. Target molecule was prepared from trans - p - Pentylcyclohexanecarboxylic acid through acylchloridation,ammonolysis, dehydration and grignard reaction. Synthesis condition of grignard reaction was researched, and the optimum reaction conditions were as follows ： with tetrahydrofuran and methylbenzene as reaction solvents,n（C6H5CH2MgCl）： n（C5H11C6H10CN） = 1：1.5 ,and 10h treaction time,a total yield of 41.5% was achieved. The structure of the compound was characterized by IR, ^1HNMR.

关 键 词：乙烷类液晶 反式-对戊基环己基苄基甲酮 合成 

分 类 号：O625.52[理学—有机化学]