宣发膜原方对胶原诱导性关节炎大鼠血清中TNF-α、IFN-γ、IL-6和IL-10影响的研究  

Effects of Xuanfa Moyuan Recipe on Serum Levels of TNF-α,IFN-γ,IL-6 and IL-10 in Collagen-induced Arthritis in Rats

作　　者：贾红伟[1] 赵宁[1] 张皖东[1] 鞠大宏[1] 徐世杰[1] 赵宏艳[1] 吕诚[1] 赵林华[1] 魏来[1] 铃木聪[2] 李艳[1] 王少君[1] 滕静如[1] 王安民[1] 吕爱平[1] 

机构地区：[1]中国中医研究院基础所,北京100700 [2]北京中医药大学,北京100029

出　　处：《中国中医基础医学杂志》2005年第11期818-820,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家自然科学基金资助项目(No.39870952)

摘　　要：目的:探讨宣发膜原方对CIA大鼠血清中TNF-α、IFN-γI、L-6和IL-10影响。方法:以CIA作为RA的动物模型,给予宣发膜原方治疗,用ELISA及放免法检测大鼠血清中TNF-α、IFN-γ、IL-6和IL-10的含量。结果:宣发膜原方可以降低大鼠血清中IFN-γ、TNF-α和IL-6(P<0.01),升高IL-10(P<0.01)。结论:宣发膜原方能够调节CIA大鼠血清中细胞因子含量。Objective： to probe the effects of Xuanfa Moyuan preparation on cytokines in serum of collagen-Ⅱ induced arthritis（CIA） rats. Methods： Rats were immunized with the complex of collagen-Ⅱ and complete Frund＇s adjuvant, TNF-α, IFN-γ, IL-6 and IL-10 in serum of CIA rats were measured with methods of ELISA and radioimmunology. Results： after CIA rats were treated with Xuanfa Moyuan preparation for four weeks, TNF-α, IFN-γ, IL-6 were decreased, and IL-10 increased. Conclusion ： Xuanfa Moyuan preparation can regulate cytokines in the serum in CIA rats.

关 键 词：宣发膜原方 细胞因子 胶原诱导性关节炎 类风湿性关节炎 痹证 

分 类 号：R285.5[医药卫生—中药学]