小檗碱对2肾1夹致心肌肥厚大鼠心室重构的影响  

Influence of berberine on left ventriculer remodeling in rats with hypertrophic cardiomyopathy induced by 2K1C

作　　者：洪缨[1] 王晶[1] 赵海苹[1] 谢俊大[1] 李玄[1] 许晓林[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《北京中医药大学学报》2005年第6期28-31,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.90209050)

摘　　要：目的观察小檗碱对2肾1夹模型大鼠心肌肥厚的抑制作用及对细胞外基质胶原含量的影响。方法采用2肾1夹法制备大鼠心肌肥厚模型,造模4周后根据动物收缩压水平将手术动物均匀分为:模型组,小檗碱5、10、20 mg/kg组,卡托普利45 mg/kg组,另设假手术对照组。连续灌胃给药6周。实验结束时,测定心重指数、左心室肌组织胶原含量和血管紧张素Ⅱ含量。结果小檗碱连续给药6周使2肾1夹模型大鼠心重和心重指数降低,左心室组织胶原含量显著下降,血管紧张素Ⅱ含量也有所减少,作用呈一定的剂量依赖关系。结论小檗碱可能通过抑制心肌间质纤维化而改善心室重构,其作用与对AngII等神经内分泌因素的调节有关。Objective To observe the inhibitory effect of berberine on hypertrophic cardiomyopathy （HCM） in the model and influence of berberine on the content of exocellular matrix collagen. Methods Two - kidney one - clip （2K1C） method was used to establish rat model of HCM. After 4 weeks the rats were divided into 5 groups according to their systolic pressure levels, including the HCM model group, the groups with 5, 10, 20 mg/kg berberine respectively and the group with 45mg/kg captopril, while the control group was given sham - operation. The drugs were orally administered for 6 weeks in different groups. Then cardiac weight indexes, contents of collagen and angiotensin Ⅱ （AngⅡ） in left ventricular tissue were measured. Results The cardiac weights and cardiac weight indexes, contents of collagen and AngⅡ in left ventricular tissue decreased in model rats after constant administration of berberine for 6 weeks. The effect of berberine was in a dose - dependent manner. Conclusion Berberine can improve the ventricular remodeling by inhibiting ventricular interstitial fibrosis, which maybe related to its regulation effect on AngⅡ and some other nervous endocrine factors.

关 键 词：小檗碱 心室重构 胶原 血管紧张素Ⅱ 大鼠 

分 类 号：R285.5[医药卫生—中药学]