白细胞介素6与急性心肌梗死后心室重构的相关性  

Correlation of interleukin-6 and post-myocardial infarction left ventricular remodeling

作　　者：马永娜[1] 李拥军[1] 赵伟 张辉[1] 杨蓉[1] 苏便苓[1] 

机构地区：[1]河北医科大学第二附属医院心内科,河北石家庄050000 [2]武警8640医院,河北定州073000

出　　处：《临床荟萃》2005年第23期1326-1328,共3页Clinical Focus

摘　　要：目的探讨白细胞介素6(IL-6)与心肌梗死后早期心室重构(LVRM)的关系,为急性心肌梗死患者病情评估与预后判断提供理论依据。方法选择发病12小时内的首次急性Q波心肌梗死患者64例,测定发病72小时的血清IL-6浓度以及第14天的超声心动图。按照IL-6浓度分为低IL-6组(IL-6<10 ng/L)、高IL-6组(IL-6≥10 ng/L),比较两组间左室射血分数(LVEF)、左室收缩末容积(LVESV)、左室舒张末容积(LVEDV)、室壁瘤及总的LVRM的发生率。结果高IL-6组较低IL-6组LVEF降低(52.29±11.45)%比(58.11±9.83)%(P<0.05),而LVEDV、LVESV、室壁瘤发生率、左室重构发生率均升高(P<0.05)。相关分析:IL-6与LVEDV、LVESV、室壁瘤及左室重构均呈显著正相关(P<0.05),与LVEF呈显著负相关(P<0.05)。结论急性心肌梗死后72小时血清IL-6浓度与梗死后心室重构发生率呈正相关,是预测心肌梗死后发生心室重构的敏感性指标。Objective To investigate the relationship of serum interlenkin-6（IL-6） level and post-infarction left ventricular remodeling（LVRM） for condition and prognosis judgement of acute myocardial infarction（AMI）. Methods Sixty-four patients with first Q-wave AMI within 12 hours after symptom onset were admitted. Serum IL-6 at 72 hours of onset and hospital echocardiogram at 14 days of onset were obtained. The patients were divided into two groups according to IL-6 level： low IL-6 group（IL-6〈10 ng/L）, high IL-6 group （IL-6〈10 ng/L）. The parameters including left ventricular ejection fraction （LVEF）, left ventricular end-systolic volume （LVESV）, left ventricular end-diastolic volume（LVEDV）, the ratio of cardiac aneurysm and left ventricular remodeling（LVRM） were compared. Results Compared with low IL-6 group, LVEF was lower in high IL-6 group（ P d0.05）, but LVESV, LVEDV, the ratio of cardiac aneurysm and LVRM increased in high IL-6 group（ P 〈0.05）. LVESV, LVEDV, cardiac aneurysm and LVRM were positively correlated with serum IL-6. LVEF was negatively correlated with serum IL-6 （ P〈0.05）. Conclusion Serum IL-6 at 72 hours of AMI onset is a sensitive predictor of post-myocardial infarction left ventricular remodeling. It may be a useful factor to evaluate the cardiac function and prognosis.

关 键 词：心肌梗塞 心室重构 白细胞介素6 

分 类 号：R541.4[医药卫生—心血管疾病]