基因选择性剪接的生物信息学研究概况  

The Application of Bioinformatics in the Research of Alternative Splicing

作　　者：林鲁萍[1] 马飞[1] 王义权[1] 

机构地区：[1]厦门大学生命科学学院,厦门361005

出　　处：《遗传》2005年第6期1001-1006,共6页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:60305001;30470938)资助~~

摘　　要：基因选择性剪接现象是真核生物基本而又重要的调控机制。由于基因的选择性剪接在形成生物复杂性和多样性上具有极其重要的作用,同时选择性剪接与许多人类疾病也密切相关。因此,研究基因选择性剪接是一项十分重要的工作。生物信息学作为一门新兴的学科在研究基因选择性剪接上起关键的作用,尤其在研究基因表达调控机制、选择性剪接基因预测以及选择性剪接基因进化上。文章综述了这方面的最新研究进展,为更深入了解真核生物基因的表达调控机理提供依据。Alternative splicing, a fundamental and important regulatory mechanism in eukaryotes, allows one pre-mRNA to be processed into many different mature forms within a cell, each of which can have distinct functions. As alternative splicing is associated with human diseases, the study of alternative splicing becomes quite important. Bioinformatics is a new subject for the study of alternative splicing, especially for its regulatory mechanism, prediction and origin. Of course, bioinformatics must be combined with experimental research so as to clarify these aspects of alternative splicing. This paper reviewed the recent research progress in this field in the hope to gain a deeper understanding of eukaryotic gene expression regulation.

关 键 词：选择性剪接 生物信息学 基因组 

分 类 号：Q753[生物学—分子生物学]