蓍草提取物防治肝纤维化大鼠脂质过氧化作用的实验研究  

Experimental Study of Extract of Achillea millefoliun L on Lipid Peroxidation of Hepatic Fibrosis

作　　者：洪振丰[1] 陈艳华[1] 李天骄[1] 

机构地区：[1]福建中医学院中西医结合系,福建福州350003

出　　处：《福建中医学院学报》2005年第6期23-25,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省科技三项费用资助项目(K02086)

摘　　要：为研究中药蓍草对肝组织纤维化过程中脂质过氧化的防治作用,观察了蓍草醇提取物防治CCL4诱发的大鼠肝纤维化过程中脂质过氧化作用的效果。结果:蓍草醇提物可有效提高肝组织超氧化物岐化酶(SOD)的含量、降低自由基脂质过氧化反应终产物丙二醛(MDA)的含量。结论:蓍草醇提取物可能通过减轻氧自由基对肝细胞的破坏对肝细胞起到保护作用。To study the prophylaxis and anti-lipid peroxidation effect of the extract of Achillea millefoliun L on experimental hepatic fibrosis induced by CCL4. The result showed that the extract of Achillea millefoliun L could elevate the content of SOD and reduce the abnormally high levels of MDA （malondialdehyde）. Conclusion： Extract of Achillea millefoliun L can protect hepatocytes from injury and prevent the progress of hepatic fibrosis by anti-lipid peroxidation effect in rats, which may associate with the effect of anti-oxidiation of the extract.

关 键 词：蓍草 大鼠 肝纤维化 脂质过氧化 

分 类 号：R285.5[医药卫生—中药学]