中老年知识分子骨质疏松危险因素病例-对照研究  

RISK FACTORS OF OSTEOPOROSIS AMONG MIDDLE AND OLD AGE INTELLECTUALS-A CASE-CONTROL STUDY

作　　者：邝建[1] 王敏霓[2] 王声涌[2] 崔长安[3] 刘国宁[3] 

机构地区：[1]广东省人民医院内分泌科,510080 [2]暨南大学医学院流行病学教研室 [3]暨南大学医学院公共卫生学教研室

出　　处：《中华内分泌代谢杂志》1996年第1期12-16,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：对157例（男70,女87）以跟骨X线摄片和桡骨单光子骨密度测定诊断的骨质疏松患者进行了1∶1配对病例-对照研究。结果发现,与运动、饮食、喝茶及妇女月经情况有关的多种因素与骨质疏松发病危险存在密切的关联。经多因素条件Logistic回归分析:低钙饮食、40岁前综合运动指数、40岁后平均运动时间、妇女绝经年数及每月平均喝茶量是调查人群最重要、最有预测力的危险因素;无论男女,早期缺乏运动比晚期缺乏运动的危险性大,低钙饮食在女性的作用较男性大,缺乏运动对男性的发病风险更重要。提示在不同性别,骨质疏松危险因素存在差异。由于喝茶在调查人群的发病危险中也起着重要的、不可忽视的作用,而我国中老年知识分子有长期、大量饮茶的习惯,故值得作进一步的研究。In order to explore the risk factors of osteoporosis , a 1:1 matched case-control study was conducted on 157 pairs of intellectuals with age above 40 years. Bone mineral density of distal radius was measured using single photon absorptiometry and radiograph of calcaneus was classified according to Jhamaris's method.Multivarious factors related to diet, physical exercise, tea drinking, smoking,menstrual and reproductive history were significantly associated with osteoporosis. In a multiple conditional logistic regression model, low calcium intake, exercise index before 40 years of age, average time of exercise per week above 40 years old, tea consumption, and the number of years after menopause in women were the most important and predictive factors. The risk led by lower calcium intake was higher in women than in men. The risk due to lack of regular exercise was more prominent in men,but for both sexes lack of exercise in early years of life was more risky than that in later years. As many people have habit of excessive tea drinking, the exact effect of tea on osteoporosis deserves further study.

关 键 词：骨质疏松 危险因素 病例-对照研究 

分 类 号：R681.02[医药卫生—骨科学]