Hβ沸石催化酰基化合成4-甲氧基二苯甲酮  

Friedel-Crafts acylation catalyzed by zeolite Hβ to synthesize 4-methoxybenzophenone

作　　者：袁冰[1] 乔卫红[1] 颜杰[2] 李宗石[1] 王桂茹[1] 程侣柏[1] 

机构地区：[1]大连理工大学精细化工国家重点实验室,辽宁大连116012 [2]四川理工学院应用化学系,四川自贡643000

出　　处：《大连理工大学学报》2005年第6期789-792,共4页Journal of Dalian University of Technology

摘　　要：采用高硅铝比、热稳定性好的三维大孔Hβ沸石替代传统Lewis酸催化剂催化苯甲醚的苯甲酰化反应,合成了重要精细化工中间体4-甲氧基二苯甲酮,收率可达92%.反应的主要副产物为2-甲氧基二苯甲酮和苯甲酸苯酯.考查了催化剂用量、原料配比、反应时间对目标产物收率的影响,发现10 g/mol的催化剂用量和1.4:1～1.6:1的原料配比为最适宜的反应条件.Hβ沸石催化活性高,选择性好,反应周期短.反应中过量的苯甲醚可充当溶剂,替代传统的极性溶剂,使反应操作简单、工艺清洁,易于后处理.A three-dimensional large pore zeolite Hβ is used in the benzoylation of anisole instead of the classical Lewis acid catalysts to synthesize the important fine chemical intermediate 4-methoxybenzophenone. The yield of 4-methoxybenzophenone can reach 92%, and the main by-products are 2-methoxybenzophenone and phenol benzoate. The influence on yield of amount of catalyst, benzoyl chloride to anisole molar ratio and reaction time are studied. It is found that 10 g/mol catalyst and 1.4 ： 1～1.6：1 （molar ratio） are optimal. Zeolite Hβ as the catalyst of the benzoylation of anisole shows excellent activity and high selectivity. Excessive anisole is used instead of the classical polar solvent, which leads to clean reaction, simple operation and easyafter-treatment.

关 键 词：4-甲氧基二苯甲酮 HΒ沸石 Friedel-Crafts酰基化 

分 类 号：O643.322[理学—物理化学] TQ244.2[理学—化学]