基于全蛋白质组的微生物系统发育树构建  

Construction of phylogenetic tree of whole proteome microbial organisms as inferred from a new measure of information discrepancy

作　　者：张文[1] 唐焕文[1] 方伟武[2] 蔡旭[2] 张伟伟[1] 

机构地区：[1]大连理工大学计算生物学和生物信息学研究所,辽宁大连116024 [2]中国科学院应用数学研究所,北京100080

出　　处：《大连理工大学学报》2005年第6期925-930,共6页Journal of Dalian University of Technology

基　　金：国家自然科学基金资助项目(9010303320176005)

摘　　要：新近出现的信息离散性度量方法(简称FDOD方法)已在多个领域获得成功的应用,是一种非比对距离方法.随着越来越多的微生物全基因组测序任务的完成,人们开始在整个基因组水平上探讨物种的系统发育关系.因此,将FDOD方法应用于微生物系统发育分析是一项很有意义的工作.因为氨基酸序列比DNA序列更为保守,能为物种的进化分析提供更为有用的信息.对收集到的163个原核生物和5个真核生物,从完全蛋白质组出发去分析推断其系统的发育关系,所得的系统发育树包括145个细菌、18个古细菌和5个真核细菌,这与三界进化理论符合,大部分低层分支与权威的《伯杰氏系统细菌学手册》相同.并且对高层分支关系提出了一些新建议.A new measure of information discrepancy noted by FDOD for short appeared recently. With the accomplishment of more and more microbial genome sequencing, people have begun to study phylogenetics on the standard of whole genome. So applying the FDOD to infer the phylogeny of whole proteome microbial organisms is significant work. Because the amino acid is more conservative than DNA sequence, it can offer more important information for studying phylogenetics. To study deeply, phylogenetics on the standard of whole proteome microbial organisms for 163 procaryotic organisms and 5 eucaryotic organisms are studied. The results show that the phylogenetic tree, including 145 bacteria, 18 archaea, and 5 eukarya, agrees with the “Bergey＇s Manual of Systematic Bacteriology” in a majority of lower taxa. In addition, some suggestions are given on higher taxa.

关 键 词：微生物 原核生物 古细菌 系统发育 信息离散性度量 

分 类 号：Q517[生物学—生物化学] Q349