补肾密骨液对大鼠卵巢切除诱导的实验性骨质疏松症的影响  

EffectofBushenMiguYeonOsteoporosisInducedbyOvariectomy:AnExperimentalStudy

作　　者：杜靖远[1] 沈霖[1] 杨家玉[1] 谢晶[1] 杨艳萍[1] 高兰[1] 周丕祺[1] 

机构地区：[1]同济医科大学附属协和医院骨科

出　　处：《中华骨科杂志》1996年第7期462-464,共3页Chinese Journal of Orthopaedics

摘　　要：运用骨组织形态计量学观察了中药补肾密骨液对大鼠切除卵巢诱导的实验性骨质疏松症模型的影响，并与防治骨质疏松药尼尔雌醇及生理盐水进行对照．结果显示，中药组及尼尔雌醇组骨小梁密度显著高于盐水组，破骨细胞指数明显低于盐水组（Ｐ值＜０．０５）．在类骨质含量及骨形成参数值测量中，中药组明显高于尼尔雌醇及盐水组（Ｐ值＜０．０５）．提示：补肾密骨液不仅能抑制破骨细胞的骨吸收活动，还能增生成骨细胞，产生较多的骨基质，使模鼠的骨代谢恢复正态平衡．HistomorphometricmeasurementwasusedtoobservetheeffectofBushenMiguYe(BSMGY)-amixtureofChineseherbmedicineonosteoporosisinratsfolowingovariectomy.48ani-malswererandomlydividedinto4groups.Thecontrolgroupwasgivennothingfolowingovariectomyfortheobservationofthedevelopmentofosteoporosis.Theexperimentalgroupswererespectivelygiv-enBSMGY,Nilestriol(NLST)andnormalsaline(NS)folowingsurgeryforthecomparativestudyoftheirefectonosteoporosis.AnalysisofthedatashowedthatthetrabeculardensityofthegroupsgivenBSMGYandNLSTwerehigherandtheosteoclasticindiceswerelowerthanthatofthegroupgivenNS(P<0.05).TheparametersrelatedtoboneformationandosteoidcontentinthegroupgivenBSMGYweresignificantlyhigherthanthatobservedintheNLSTandNSgroups(P<0.05).ThispreliminarystudysuggestedthatBSMGYisabletoinhibitboneresorptionactivityofosteoclastsandalsotoin-creasethenumberofosteoblaststoproducemoreosteoidandthusenhancingtherecoveryofpositivebalanceonthecancelousboneremodelingintheosteoporosismodel.

关 键 词：补肾密骨液 骨质疏松 卵巢切除术 

分 类 号：R269.1[医药卫生—中西医结合] R274.91[医药卫生—中医外科学]