多种肿瘤标记物蛋白芯片在肝癌诊断中的应用  

The value of multiple tumor marker protein biochip detection system in the diagnosis of hepatoma.

作　　者：王海枫[1] 梁茱[1] 吴爱祝[1] 符生苗[1] 

机构地区：[1]海南省人民医院中心实验室,海南海口570311

出　　处：《中国热带医学》2005年第9期1798-1799,1806,共3页China Tropical Medicine

摘　　要：目的研究多肿瘤标志物蛋白芯片诊断系统用于肝癌的临床诊断价值。方法用多肿瘤标志物蛋白芯片诊断系统测定分析263例肝癌患者、113例良性肝病患者和130例健康体检者血清CA199、NSE、CEA、CA242、Ferriting、β-HCG、AFP、f-PSA、PSA、CA125、HGH、CA153等12种肿瘤标志物。结果C12联合检测肝癌组的阳性率为91·6%,良性肝病组为15·9%,正常对照组为4·6%,肝癌组阳性率显著高于良性肝病组和正常对照组(χ2=89·39,P<0·01;χ2=137·96,P<0·01)。结论多肿瘤标志物蛋白芯片检测系统的应用对肝癌诊断有较高的临床参考价值。Objective To discuss the clinical diagnosis value of multi - tumor markers protein biochip in hcpatoma, Methods The content of 12 Tumor Markcrs（CA199、NSE、CEA、CA242、Ferriting、β-HCG、AFP、f-PSA、PSA、CA125、HGH、CA153） in 263 hcpatoma patients , 113 benign hcpatopathy patients and 130 healthy subjects by using protein chip technique. Results The positive rates in the of the group of hcpatoma patients, benign hcpatopathy patients and healthy subjects were 91.6%, 15.9%, and 4. 6 %, respectively. The positive rate in the group of hcpatoma patients is obviously higher than that of the group of benige hcpatopathy patients and healthy subjects （X^2 = 89.39, P 〈 0. 01; X^2 = 137.96, P 〈 0.01 ）, Conclusion Multi - tumor markers protein biochip has significant clinical value in the diagnosis of hcpatoma.

关 键 词：肝癌 肿瘤标志物 蛋白芯片 

分 类 号：R735.7[医药卫生—肿瘤]