饮水补镁对动脉粥样硬化大鼠血脂及炎性因子的影响  

Magnesium Fortification of Drinking Water Induces Favorable Changes in Blood Lipoprotein and Inflammation Factors on An Atherosclerotic Rat Model

作　　者：郑璇[1] 龚孝淑[1] 蔡东联[2] 季燕[3] 

机构地区：[1]第二军医大学附属长征医院护理教研室,上海200003 [2]第二军医大学附属长海医院营养科 [3]第二军医大学附属长海医院实验诊断科

出　　处：《中国临床营养杂志》2005年第5期281-284,共4页Chinese Journal of Clinical Nutrition

基　　金：国家高技术研究发展计划项目(863项目)(2002AA2Z346C)

摘　　要：目的观察饮水补镁对大鼠血脂及炎性因子的影响,探讨镁对动脉粥样硬化预防的可能机制。方法 Wistar大鼠随机分为正常对照组、模型组和高镁组,喂养8周后采集制备血清及组织匀浆,测定炎症标志物肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及血脂并进行病理评分。结果模型组大鼠心肌及主动脉IL-6、TNF-α显著高于高镁组和对照组(P＜0.05),血清TNF-α未测及,模型组血清IL-6显著高于其他2组(P＜0.01)；高镁组、模型组血清总胆固醇(TC)、甘油三酯、低密度脂蛋白胆固醇均显著高于对照组(P＜0.05),但高镁组中三者均显著低于模型组(P＜0.05),同时高密度脂蛋白胆固醇／TC显著高于模型组(P＜0.05)；主动脉内膜斑块评分高镁组低于模型组(P＜0.05)。结论适当饮水补镁有助于调节机体炎性因子,预防动脉粥样硬化。Objective To observe the influence on blood lipopmtein and inflammation factors induced by magnesium-added water, and to investigate potential protective mechanism of magnesium on atherosclerosis in rats. Methods The concentration of blood lipids, tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） in serum, and homogenized tissue were determined, and the pathological changes of aorta were evaluated in control group （normal diet and water）, model group （high-fat diet and normal water） and study group （high-fat diet and magnesium fortified water） at the end of week 8. Results TNF-α and IL-6 in myocardium and aorta were significantly higher in modal group than those in study group and control group （P 〈 0.05）. Serum TNF-α was not detected. Serum IL-6 in model group was significantly higher than in the other two groups （P 〈 0.01）. Lipid file analysis showed that total cholesterol （TC）, triglyceride, and low density lipoprotein-cholesterol in model group and the study group were significantly higher than that in control group （P 〈 0.05）, and they were significantly lower in study group than in model group （P 〈 0.05）. High density lipoprotein-cholesterol/TC in study group were significantly higher than in model group （P 〈 0.05）. Atherosclerotic evaluations scores were significantly lower in study group than that in model group （P 〈 0.05）. Conclusion Magnesium is beneficial to prevent atherosclerosis through down-regulation of inflammatory factors.

关 键 词：镁 动脉粥样硬化 肿瘤坏死因子Α 白细胞介素-6 

分 类 号：R543.5[医药卫生—心血管疾病]