积雪草化学成分研究  

Chemical constituents from whole plant of Centella asiatica

作　　者：张蕾磊[1] 王海生[2] 姚庆强[1] 刘拥军[1] 栾阳[1] 王秀丽[1] 

机构地区：[1]山东省医学科学院药物所,山东济南250062 [2]山东大学第二医院,山东济南250062

出　　处：《中草药》2005年第12期1761-1763,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的研究积雪草Centella asiatica的化学成分。方法采用各种色谱技术进行分离纯化,通过理化性质和波谱分析进行结构鉴定。结果从积雪草中共分离得到14个化合物,其结构鉴定为β-谷甾醇(Ⅰ)、二十六醇辛酸酯(Ⅱ)、山柰酚(Ⅲ)、槲皮素(Ⅳ)、胡萝卜苷(Ⅴ)、香草酸(Ⅵ)、丁二酸(Ⅶ)、积雪草酸(Ⅷ)、羟基积雪草酸(Ⅸ)、ter-minolic acid(Ⅹ)、积雪草苷(Ⅺ)、积雪草二糖苷(Ⅻ)、羟基积雪草苷、积雪草苷-B。结论化合物为一新化合物;羟基积雪草酸和terminolic acid、羟基积雪草苷和积雪草苷-B为两对同分异构体。Objective To study the chemical constituents in Centella asiatica. Methods Isolation by use of various chromatographic techniques, structure identification by their physico-chemical properties as well as various spectral data. Results The structures of 14 constituents in C. asiatica were determined, which were β-sitosterol （ Ⅰ ）, hexacosanol octanoate （ Ⅱ ）, kaempferol （ Ⅲ ）, quercetin （Ⅳ）, daucosterol （ Ⅴ ）, vanillic acid （ Ⅵ ）, succinic acid （Ⅶ）, asiatic acid （Ⅷ）, madecassic acid （Ⅸ ）, terminolic acid （ Ⅹ ）, asiaticoside （Ⅺ）, asiaticodiglycoside （Ⅻ）, madecassoside （ⅩⅢ）, asiaticoside-B （ⅩⅣ）. Conclusion Compound Ⅻ is a new compound. Madecassic acid and terminolic acid, madecassoside and asiaticoside-B are two couples of isomeric compounds.

关 键 词：积雪草 积雪草二糖苷 皂苷类 

分 类 号：R284.1[医药卫生—中药学]