Apgar评分与CK-MB和cTnI的相关性及临床应用  

Study on correlation between Apgar and CK-MB,cTnI and its clinical usage

作　　者：高彬昌[1] 栾桂珍[1] 冯金环[1] 栾红[1] 

机构地区：[1]青岛大学医学院附属海慈医院儿科,266033

出　　处：《中国妇幼保健》2005年第23期3085-3087,共3页Maternal and Child Health Care of China

摘　　要：目的:通过Apgar评分和CK-MB、cTnI含量的测定,为早期评价缺血缺氧性心肌损害并进行干预提供理论依据。方法:记录出生后72 h内的心脏事件并于出生后24 h、72 h、7 d测定不同Apgar评分新生儿血清CK-MB、cTnI含量,然后进行分析。结果:血清CK-MB、cTnI的含量随时间延长逐渐下降(P<0.01),同一时间点在有窒息组和无窒息组之间有显著差异(P<0.01),有窒息组组间也有显著差异(P<0.01),无窒息组组间差异无统计学意义(P>0.05)。心脏事件的发生率随Apgar评分的增加逐渐降低(P<0.01)。Apgar 1 m in评分与CK-MB、cTnI 24 h测定值之间具有很好的相关性(P<0.01)。结论:Apgar评分和CK-MB、cTnI均可作为缺血缺氧性心肌损害的评价指标。Objective： To provide some theoretical evidences for early evaluating hypoxic -ischemic myocardial injury and giving therapy. Methods： The neonates were selected through Apgar, with 104 newborns as the group of asphyxia and 52 non -asphyxia. The content of CK - MB and cTnI in serum were measured at the time of 24 h, 72 h and 7 d after birth. The myocardial events were written out within 72 h after birth. Results： The contents of CK - MB and cTnI decreased gradually with time elongating （P 〈0. 01 ） . There existed a difference （P 〈0. 01 ） between the groups of asphyxia and non - asphyxia at the given time; while the groups within non - asphyxia had no statistic difference （P 〉0. 05 ） , The ratio of myocardial events decreased with Apgar increasing （P 〈 0.01 ） . There was a good correlation between Apgar by 1 minute and the content of CK - MB, cTnI by 24 hour （P 〈0. 01 ） . Conclusion： Apgar, CK - MB and cTnI can all evaluate hypoxic - ischemic myocardial injury as a criterion.

关 键 词：APGAR评分 CK—MB CTNI 窒息 新生儿 

分 类 号：R722.12[医药卫生—儿科]