六种治疗方案对1910例甲型肝炎和233例急性乙型肝炎患者疗效分析  

Clinical observation on six projects in 1910 patients with hepatitis A and 233 with acute hepatitis B

作　　者：赵志刚[1] 王献青[1] 夏冬[1] 任凯[1] 吴迪[1] 汪丽[1] 孔宪伟[1] 曹春玲[1] 刘兰芳[1] 许桂玲[1] 

机构地区：[1]解放军第210医院传染科,辽宁省大连市116021

出　　处：《实用肝脏病杂志》2005年第6期328-330,339,共4页Journal of Practical Hepatology

摘　　要：目的回顾性观察甘草酸二胺(5组)、单胺(6组)、山莨菪碱(2组)、门冬氨酸钾镁(3组)、山莨菪碱+门冬氨酸钾镁注射液(4组)、茵黄片(1组)治疗甲型肝炎和急性乙型肝炎患者的疗效.方法甘草酸二胺150mg、单胺40ml、山莨菪碱10mg、门冬氨酸钾镁20ml分别加入5%～10%葡萄糖注射液250ml中静脉滴注,口服茵黄片治疗甲型肝炎和急性乙型肝炎共2143例,治疗结束后进行疗效分析.结果甲型肝炎、急性乙型肝炎患者的治愈率分别为96.3%、94.4%.甲型肝炎组中,甘草酸二胺、单胺可使患者平均住院日、纳差、乏力消失、丙氨酸氨基转移酶(ALT)、血清胆红素(SB)复常的时间较其他组分别缩短5～7、2～4、1～2、4～7、4～8天,差异有显著性(P＜0.02～0.001).1组患者纳差、巩膜黄染、肝区叩痛消失时间较其他组分别延长1～4、1～8、2～5天,差异有显著性(P＜0.05～0.001).急性乙型肝炎组中,5、6组患者的平均住院日、ALT、SB复常时间为36.2、35.1,23.7、23.9,19.1、19.0天,较其他组缩短7～11、4～6、5～7天,恶心、纳差消失时间为10.9、10.5,13.0、13.7天,较1组患者缩短2～3天,乏力消失时间为14.6、15.0天,较1、2组患者缩短3～5天(P＜0.05～0.01).结论在治疗甲型肝炎和急性乙型肝炎时,甘草酸二胺和单胺在改善患者临床症状和肝功能指标方面优于茵黄片、山莨菪碱和门冬氨酸钾镁等药物,甘草酸二胺、单胺在治疗甲型肝炎和急性乙型肝炎中疗效相当.口服茵黄片的疗效低于静脉应用药物.Objective To retrospectively analyze the effect of monomnmonium glycyrrhizinate （the sixth group）, diammonium glycyrrhizinate （the fifth group）, anisodamine injection （the second group）, potassium megneium aspartate panangin injection （the third group）, anisodamine plus potassium megneium aspartate panangin injection （the fourth group）, yinhuang tablet （the first group） in the patients with hepatitis A and acute hepatitis B. Methods 2143 patients （ 1910 cases with hepatitis A and 233 cases with acute hepatitis B） were treated with 4Oral monoammonium glycyrrhizinate, 150mg diammonium panangin injection, 10mg anisodamine injection, 20ml potassium megneium aspartate pangagin injection added into 250ml of 5 % to 10% glucose respectively, or treated with yinhuang tablets. Results The cure rates of the patients with hepatitis A and acute hepatitis B were 96.3 %, 94.4 % respectively. In the hepatitis A group, the average hospitalization duration, the disappearance duration of poor appetite and hypodynamia, the recovery duration of ALT, SB in the fifth and sixth group were shortened for 5 ～7days,2 ～4days, 1～ 2days,4 ～7 days,4 ～ 8days than other groups respectively（ P 〈 0.02 ～0.001 ）. The disappearance durations of poor appetite, ieterie selera, percussion pain at hepatic region were prolonged for 1 ～ 4 days, 1 ～ 8 days ,2 ～ 5 days than other groups respectively（ P 〈 0.05～ 0.001 ）. In the acute groups, the average hospitalization duration, the recovery duration of ALT（alanene aminotransferase）, SB（ serum bilirubin） in the fifth and sixth group were 36.2days, 35.1 days, 23.7 days, 23.9days, 19.1 days, 19.0days respectively. The three aspects were shortened for 7～ 11 days, 4 ～6days, 5～ 7days than other groups respectively. The disappearance duration of nausea, poor appetite was 10.9days, 10.5days, 13.0days, 13.7days respectively. The days were shortened for 2 ～ 3days than the first group. The disappearance duration of hypodynamia was 14.6days, 15.0d

关 键 词：甲型肝炎 急性乙型肝炎 甘草次酸 山莨菪碱 门冬氨酸钾镁 

分 类 号：R512.6[医药卫生—内科学]