中红外光纤光谱法用于甲状腺肿物的体表、在体及离体检测研究  

Detection of the Thyroid Tumor via Percutaneous,in vivo and in vitro Examination Using FT-mid-IR Fiber Optics Spectroscopy

作　　者：徐怡庄[1] 赵莹[2] 徐智[3] 杨丽敏[4] 刘玉峰[1] 凌晓锋[3] 张能维[5] 王立新[3] 王冰冰[1] 孟涛[2] 张元福[1] 翁诗甫[1] 周孝思[3] 徐端夫[2] 吴瑾光[1] 

机构地区：[1]北京大学化学与分子工程学院稀土材料化学及应用国家重点实验室,北京100871 [2]中国科学院化学研究所,北京100080 [3]北京大学第三医院,北京100083 [4]北京大学物理学院重离子物理研究所,北京100871 [5]北京铁路总医院,北京100038

出　　处：《高等学校化学学报》2005年第12期2227-2229,共3页Chemical Journal of Chinese Universities

基　　金：国家重点基础研究发展规划项目(批准号:2002CCA01900);国家自然科学基金(批准号:30371604;50203001);教育部博士学科点基金资助

摘　　要：In the present paper,FT-mid-IR fiber optics spectroscopy was used to determine the thyroid tumor.A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work.Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients,in vivo detection and in vitro measurement of six patients in operation room was also carried out.The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination,the in vivo measurement and freshly resected thyroid tissues.The relative intensity and peak position of the IR bands in the region of 1 700-1 500 cm-1（amide Ⅰ and amide Ⅱ）,1 480-1 400 cm-1,and 1 320-1 200 cm-1 are reliable spectral marker or indexes for tumor detection.These results demonstrate that FT-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.In the present paper, FF-mid-IR fiber optics spectroscopy was used to determine the thyroid tumor. A modified WQF-500 FTIR spectrometer with MCT detector and mid-IR fiber optics ATR accessory was used in this work. Percutaneous examination of the skin overlying the thyroid tumor was performed on five patients, in vivo detection and in vitro measurement of six patients in operation room was also carried out. The experimental data indicate that malignant and benign thyroid tumor could be distinguished from the spectra of percutaneous examination, the in vivo measurement and freshly resected thyroid tissues. The relative intensity and peak position of the IR bands in the region of 1 700--1 500 cm^-1 （ amide Ⅰ and amide Ⅱ ） , 1 480- 1 400cm^-1, and 1 320-1 200cm^-1 are reliable spectral marker or indexes for tumor detection. These results demonstrate that FF-mid-IR fiber optics spectroscopy exhibits prospect to develop a novel non-invasive method for thyroid tumor detection.

关 键 词：FrIR 中红外光纤 甲状腺肿瘤 检测 

分 类 号：O657.33[理学—分析化学]