EEG-correlated fMRI of P3b component in P300 waves  

作　　者：LI Yuezhi WANG Liqun WANG Mingshi 

机构地区：[1]College of Engineering and Technology, Shenzhen University, Shenzhen 518060, China [2]College of Precision Instrument and Opto-electronics Engineering,Tianjin University, Tianjin 300072, China [3]Applied Superconductivity Research Laboratory, Tokyo Denki University, Chiba, Japan

出　　处：《Chinese Science Bulletin》2005年第21期2448-2456,共9页

摘　　要：Electroencephalography-correlated functional magnetic resonance imaging (EEG/fMRI) can be used to identify blood oxygen level-dependent (BOLD) signal changes associated with both physiological and pathological EEG events. Here, we implemented continuous and simulta-neous EEG/fMRI to identify BOLD signal changes related to P3b component of P300, and 64 channels of EEG were re-corded in 11 subjects during Landot Ring task inside a 1.5 T functional magnet resonance (MR) scanner using an MR-compatible EEG recording system. Functional scanning by echoplanar imaging covered almost the entire cerebrum every 2 s, leaving gaps of 2 s without scanning. Off-line MRI artifact subtraction software was applied to obtain continu-ous EEG data. Additionally, a P300 wave matched filter was constructed to inspect P300 wave occurrence following every target stimulus, target stimuli inspected to induce P300 were detected and their MRI scan number were then used as input for an event-related fMRI analysis. Finally MRI statistical parametric maps were constructed and corrected for multi-ple comparisons. By random effect group analysis, activa-tions were detected in the right superior parietal lobule and bilaterally in inferior parietal lobule(p<0.001, uncorrected). The results demonstrated the upper regions were sources of P3b component and involved in target detection in memory comparison task.Electroencephalography-correlated functional magnetic resonance imaging （EEG/fMRI） can be used to identify blood oxygen level-dependent （BOLD） signal changes associated with both physiological and pathological EEG events. Here, we implemented continuous and simultaneous EEG/fMRI to identify BOLD signal changes related to P3b component of P300, and 64 channels of EEG were recorded in II subjects during Landot Ring task inside a 1.5 T functional magnet resonance （MR） scanner using an MR-compatible EEG recording system. Functional scanning by echoplanar imaging covered almost the entire cerebrum every 2 s, leaving gaps of 2 s without scanning. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data. Additionally, a P300 wave matched filter was constructed to inspect P300 wave occurrence following every target stimulus, target stimuli inspected to induce P300 were detected and their MRI scan number were then used as input for an event-related fMRI analysis. Finally MRI statistical parametric maps were constructed and corrected for multiple comparisons. By random effect group analysis, activations were detected in the right superior parietal lobule and bilaterally in inferior parietal lobule（p〈0.001, uncorrected）. The results demonstrated the upper regions were sources of P3b component and involved in target detection in memory comparison task.

关 键 词：脑电图 MRI 核磁共振成像 滤波器 信号变化 

分 类 号：R445[医药卫生—影像医学与核医学]