辛伐它汀对血管钙化组织中骨形成蛋白-2表达的影响  

Effect of Simvastatin on Expression of BMP-2 in Calcified Vessels

作　　者：沈丽[1] 殷峻[1] 卢维晟[1] 姚俊宇[1] 杨旭峰[1] 王一尘[1] 

机构地区：[1]上海第二医科大学新华医院老年科,上海200092

出　　处：《上海第二医科大学学报》2005年第11期1123-1125,共3页Acta Universitatis Medicinalis Secondae Shanghai

基　　金：上海市卫生局科研基金(004L13)资助项目

摘　　要：目的探讨辛伐它汀对血管钙化组织中骨形成蛋白-2(BMP-2)表达的影响。方法28只清洁级雄性SD大鼠,分为正常对照组、V it D3组、辛伐他汀组,9周后处死大鼠,观察分析其动脉钙化和BMP-2表达情况。结果正常组血管壁没有BMP-2表达,V it D3组BMP-2表达明显,辛伐他汀组BMP-2表达较V it D3组显著减少(P<0.01)。结论辛伐他汀能降低血管钙化组织中BMP-2表达,这可能是辛伐他汀对血管钙化具有保护作用的因素之一。Objective To study the effect of simvastatin on the expression of BMP-2 in calcified vessels. Methods Twenty-eight male healthy SD rats were divided in three groups： control, Vit D3-treated rats and simvastatin-treated rats. Morphological changes of arterial calcification and expressions of BMP-2 in the aorta were observed after 9 weeks intervention. Results BMP-2 was absent in normal vessels and was present in calcified vessels induced by Vit D3 , which was significantly down-regulated in simvastatin-treated rats （ P 〈 0. 01 ）. Conclusion Simvastatin can reduce the expression of bmp-2 in calcified vessels. It may attribute to the beneficial effect of simvastatin on protecting vesels.

关 键 词：血管钙化 骨形成蛋白-2 辛伐他汀 

分 类 号：R96[医药卫生—药理学]