HCV感染的献血者的肝组织学和血清学变化观察  

Observation on the Hepatic Histology and Serology Changes in HCV-infected Blood Donors

作　　者：史宣玲[1] 季阳[1] 任勤惠[1] 朱志议[1] 倪声全 彭登厚 胡力 

机构地区：[1]中国医学科学院,中国协和医科大学输血研究所,610081 [2]四川省什邡县医院 [3]四川省什邡县血站

出　　处：《中国输血杂志》1996年第2期64-65,共2页Chinese Journal of Blood Transfusion

基　　金：美国CMB基金课题

摘　　要：选取确证为HCV感染约一年半的无症状献血者7名,对其肝组织学和血清学指标进行对比研究。7例肝穿刺的组织标本在光镜下均出现病毒性肝炎早期的病理学改变特征;电镜的检查结果进一步证实了感染者处于感染早期,肝组织学病变较轻。血清学检查表明ALT均处于正常水平,HCV—RNA大多为阳性,HCV基因型大多为Ⅱ型。对血清学各指标的变化与肝脏损害的关系尚需做进一步的追踪观察。Seven asymptomatic blood donors,in whom the infection with HCV was verified,were selected. The time of their infection with HCV was one and a half years. And the research on the hepatic histology and serology indexes of the donors was performed. The liver tissue samples gotten by needle biopsy of liver ware examined under the common microscope and electron microscope,thereby the abnormal hepatic histology manifestation was found, in all the donors. The samples of seven cases have shown the pathological changes characteristic of early stage of viral hepatitis under microscope. The result of examination under electron microscope confirmed that the infected donors were located in early stage of infection,and showed the low grade hepatic histological lesion. The serological examination showed that all the seven cases had normal ALT level,and most of them were HCV RNA-positive and had genotype-II . It is necessary to conduct follow-up observation on the relationship between the changes of serological indexes and the hepatic lesion.

关 键 词：HCV感染 献血者 肝组织 血清学 

分 类 号：R512.620.1[医药卫生—内科学] R457[医药卫生—临床医学]