小剂量重组人生长激素对腹腔脓毒症病人急性相反应的影响  

Effects of low-dose recombinant human growth hormone on acute phase response in patients with abdominal sepsis

作　　者：范朝刚[1] 任建安[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所,江苏南京210002

出　　处：《肠外与肠内营养》2005年第6期335-337,共3页Parenteral & Enteral Nutrition

基　　金：全军"十五"重点课题基金资助项目(批准号:01Z013)

摘　　要：目的:了解生长激素对腹腔脓毒症病人的急性相反应的影响及其可能的机制。方法:18例腹腔脓毒症病人,在其经过外科引流术后48 h内,给予重组人生长激素0.06 mg/(kg.d),观察用药前后的急性相蛋白和细胞因子的变化。结果:在应用生长激素后,血清急性相蛋白发生明显的变化,C反应蛋白明显下降,前清蛋白、纤维连接蛋白、转铁蛋白均有明显升高,细胞因子TNF-α、IL-1β、IL-6水平也有明显变化,但与急性相反应蛋白的变化不一致。结论:小剂量重组人生长激素对轻中度腹腔脓毒症病人能降低急性相反应蛋白的浓度,提高结构蛋白的浓度。Objective ： To examine the effects of recombinant human growth hormone on the acute phase response in abdominal sepsis patients. Methods： Prospective unblinded trial was made with each patient serving as his/her own control. Eighteen abdominal sepsis patients were enrolled ranging in age from 24 to 60 yrs. All patients received 10 U/d of GH 48 hrs after performing drainage and for 7days. Resuits ： Serum concentration of constitutive proteins, acute phase protein and cytokines were measured before and 1, 3, 5 and 7 days after GH administration. GH notablely increased serum constitutive protein levels （prealbumin, transferrin, fibronectin） and decreased serum acute phase protein level （CRP）. Cytokine TNF-α, IL-1β and IL-6 had significant change after GH administration, but the changes were not relative to the change of acute phase response. Conclusion ： Low-dose rhGH effectively modulated the acute phase response by attenuating production of the hepatic acute phase protein and increasing the synthesis of constitutive proteins.

关 键 词：生长激素 腹腔脓毒症 急性相反应 

分 类 号：R656[医药卫生—外科学]