纳米羟基磷灰石/聚酰胺复合人工椎板预防脊柱后路术后椎管内瘢痕粘连的实验研究  

An experimental study of nano-hydroxyapatite/polyamide-66 composite material artificial vertebral lamina on preventing the postlaminectomy scar formation and the dura adherence

作　　者：唐文胜[1] 蒋电明[1] 安洪[1] 李帮春 孟纯阳[1] 肖智博[3] 徐兵[1] 赵波[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,400016 [2]重庆市第四人民医院骨科,400014 [3]重庆医科大学附属第一医院放射科,400016

出　　处：《中国脊柱脊髓杂志》2005年第11期675-678,i0001,共5页Chinese Journal of Spine and Spinal Cord

基　　金：国家高技术研究发展计划(863计划)子课题(2002AA326020)

摘　　要：目的:探讨纳米羟基磷灰石/聚酰胺(nano-hydroxyapatite/polyamide-66,n-HA/PA66)复合人工椎板在防止脊柱后路术后椎管内瘢痕粘连,重建脊柱后部结构完整性的价值。方法:22只1岁龄雄性家犬行L5椎板切除,实验组13只行复合人工椎板植入,另9只作空白对照。术后4、8、16、24周各时相点摄X线片,行组织学、扫描电镜观察;术后24周行MRI检查。结果:实验组术后16～24周复合人工椎板界面观察到软骨细胞及板层骨,硬膜粘连程度比对照组明显减轻(P<0.01)。术后24周时MRI显示实验组椎管完整性恢复。结论:n-HA/PA66复合材料具有良好的生物相容性,能有效阻止硬膜外粘连。Objective：To evaluate the effect of artificial vertebral lamina made from nano-hydroxyapatite/polyamide-66 （n-HA/PA66） on preventing the postlaminectomy scar formation and the dura adherence in the spinal canal,and constructing vertebral canal posterior elements integraty.nethod：Of the 22 male dogs aged one year（13 in experimental group,9 in control group） the L5 laminectomy were ressected and the L5 lamina were reconstructed in the experimental group by implanting n-HA/PA66 composite material.The plain roentgenography,histology and scanning electron microscope were used at the 4th,8th,16th and 24th week respectively after the operation.MRl was undertaken at the 24th week.Result：At the 16th-24th week after the operation,the cartilage cell and lamellar bone were observed in the experimental group.Compared with the control group,the dura adhesion in the laminoplasty segment decreased significantly（P〈0.01 ）.The reconstructed segment retained the spinal integraty.Conclusion：n-HA/PA66 composite material not only has good bioeompatibility,but also can effectively prevent the scar formation and dura adhesion.

关 键 词：纳米羟攮磷灰石 聚酰胺66 人工椎板 椎板切除术 犬 

分 类 号：R318.08[医药卫生—生物医学工程]