氟康唑治疗恶性血液病的真菌感染  

TREATMENT OF FUNGAL INFECTIONS FOR PATIENTS WITH MALIGNANT HEMOPATHY WITH FLUCONAZOLE

作　　者：田丁[1] 李亚林[1] 荆华[1] 徐娟[1] 苏力[1] 甄少波[1] 韩增红[1] 邵文硕[1] 崔晓华[1] 王韬 

机构地区：[1]首都医科大学宣武医院

出　　处：《白血病》1996年第2期80-81,共2页

摘　　要：研究了采用氟康唑（大扶康Ｄｉｆｌｕｃａｎ）治疗联合化疗后ＡＬ、ＮＨＬ共３１例真菌感染患者的效果，以制霉菌素、咪康唑和酮康唑等治疗的２４例作为对照组。观察结果表明：大扶康治疗组的有效率明显高于对黑组和制霉菌素治疗组。本组中白色念珠菌感染的病例经氟康唑治疗全部有效。大扶康治疗无效的４例中有２例不能排除疗程不足因素的影响，有１例经尸捡证实为严重的全身性多脏器曲霉菌感染。结合文献，作者认为氟度唑与其它唑类药物有共同的缺陷，即治疗曲、毛霉菌效果差。本组观察还提示，大扶康毒副作用小，患者易耐受。Thirty-one patients with fungal infections were treated intravenously withfluconazole. The clinical and laboratory response rate was 87%in this group and 29%in thecontrol group.Death related fungal infection occurred in four patients in the study group. Twocases suffered with systemic aspergillosis and one of them was confirmed by autopsy. Fluconazolewas well tolerated by all patients.

关 键 词：氟康唑 恶性 血液病 真菌感染 治疗 

分 类 号：R552.05[医药卫生—血液循环系统疾病]