微卡辅助治疗菌阳肺结核的近期效果观察  

Observation on curative effect of positive bacteria pulmonary tuberculosis treated with chemotherapy and vaccae

作　　者：李月龙[1] 矫庆辉 门文若 刘建木 

机构地区：[1]吉林省吉林市结核病防治研究所,吉林132011

出　　处：《中国防痨杂志》2005年第6期358-359,共2页Chinese Journal of Antituberculosis

摘　　要：目的评价微卡(Vaccae)治疗菌阳肺结核的临床疗效。方法169例初治菌阳肺结核和90例复治菌阳肺结核,随机分为A、B、C、D组,A组(85例)、B组(84例)采用2HRZS(E)/4HR方案;C组(45例)、D组(45例)采用3HRZA(E)/6HR方案;A、C 2组加用微卡。观察治疗后肺部病灶吸收、痰菌阴转情况。结果3个月末痰菌阴转率:A、B组分别为80.0%和65.5%,C、D组分别为71.1%和62.2%;疗程结束时痰菌阴转率A、B组分别为97.6%和84.5%,C、D组分别为95.6%和77.8%。疗程结束时胸部X线显著吸收率:A、B组分别为90.6%和75.0%,C、D组分别为82.2%和60.0%。空洞闭合:A、B、C、D组分别为85.9%、64.3%、77.8%、57.7%。结论微卡辅助治疗菌阳肺结核能提高痰菌阴转率,促进肺部病灶吸收,提高免疫细胞活性,是一种较好的免疫制剂。Objective To evaluate the clinical curative effect of bacteriological positive pulmonary tuberculosis. Methods 169 primary and 90 re - treated bacteriological positive pulmonary tuberculosis cases were divided into groups A, B, C and D randomy. Group A （85 cases） and group B （84 cases） were treated with 2HRZS（E）/ 4HR; Group C （45 Cases） and group D （45 cases） were treated with 3HRZA（E）/6HR. Vaccae was added in Group A and Group C. Then observe the foci absorption and the sputum negative conversion. Results At the end of 3 months of treatment,the sputum negative conversion rate of groups A, B, C and D was 80.0%, 65. 5% ,71.1% and 62.2% respectively.At the end of treatment,the sputum negative conversion rate of groups A, B, C and D was 97.6% ,84.5% ,95.6%and 77.8% ;the foci absorption rate to groups A,B,C,D Was separately 90.6% ,75.0% ,82.2%and 60.0% respectively;Cavity close up rate was 85.9% ,64.3% ,77.8% and 57.7% respectively. Conclusion Vaccae can improve the sputum negative conversion rate, accelerate the foci absorption and improve the vitality of immune cells. It is a good immunity injection to be recommended for expansion usage.

关 键 词：肺结核 药物疗法 微卡 疗效 

分 类 号：R521[医药卫生—内科学] R153.2[医药卫生—临床医学]