血清和胎盘白介素18与子痫前期关系的研究  

Relationship between serum and placental interleukin-18 levels and preeclampsia

作　　者：黄夏娣[1] 黄荷凤[1] 董岳 姚琦玮[1] 王焓知 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《浙江大学学报（医学版）》2005年第6期495-498,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省科技计划项目(2002C23036);浙江省教育厅科研基金项目(H20031711)

摘　　要：目的:通过观察子痫前期患者血清和胎盘白介素(IL)-18水平,并与正常妊娠比较,探讨IL-18与子痫前期发病的关系。方法:采用酶联免疫吸附法测定27例子痫前期患者(子痫前期组)和28例正常孕妇(对照组)血清和胎盘组织提取液IL-18的水平,比较2组间血清和胎盘IL-18浓度的差异,观察子痫前期患者IL-18水平的变化。结果:①子痫前期组血清IL-18水平中位数为704ng/L,高于对照组470ng/L,差异有显著性(P<0.05)。②子痫前期组胎盘IL-18水平中位数为105 ng/L,高于对照组31.5 ng/L,差异有显著性(P<0.005)。结论:子痫前期患者血清和胎盘IL-18水平较正常妊娠组显著增高,提示血清和胎盘IL-18增高是子痫前期重要的病理生理变化,IL-18可能在子痫前期的发病中起一定作用。Objective： To investigate the relationship of interleukin （IL）-18 concentrations in serum and placenta and preeclampsia. Methods： Twenty-seven patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placenta samples were taken and serum and placental IL-18 concentrations were determined by enzyme-linked immunosorbent assay （ELISA）. The levels of IL-18 in serum and placenta were compared. Results： （1） The median of serum IL-18 in patients with preeclampsia was 704 ng/L, which was significantly higher than that of control group （470 ng/L,P〈0. 05）. （2） The median of placental IL-18 in patients with preeclampsia was 105 ng/L,which was also significantly higher than that of control group （31.5 ng/L,P% 0. 005）. Conclusion： Increased serum and placental levels of IL-18 were presented in preeclampsia as compared to normal pregnancy,which might offer insight into the pathogenesis of the disease.

关 键 词：胎盘/代谢 先兆子痫/病因学 白细胞介素18/血液 子痫前期 T淋巴细胞 血清 

分 类 号：R714.245[医药卫生—妇产科学]