多取代吡啶类化合物的合成及生物活性  

Synthesis and Biological Activity of Polysubstituted Pyridine Derivatives[2]

作　　者：钟滨[1] 李正名[1] 韩亮[1] 王素华[1] 

机构地区：[1]南开大学元素有机化学研究所元素有机化学国家重点实验室,天津300071

出　　处：《应用化学》2005年第12期1354-1356,共3页Chinese Journal of Applied Chemistry

基　　金：国家重点基础研究发展计划("九七三"计划)(2003CB114400);国家自然科学基金重点项目(20432010)资助项目

摘　　要：In an attempt to search for novel compounds with agricultural bioactivity,a series of new polysubstituted pyridine derivatives,α-[2-methyl-5-cyano4-（furan-2-yl）-3-ethoxycarboxyl-pyridine-6-thio]acetamide 4a, 2-methyl-5-cyano-4-（furan-2-yl）-3-acetyl pyridine-6-thioethers [STHZ]5 and 6a were designed and synthesized by a three-step or one-step synthetic route.The structures of all the compounds prepared were confirmed by（elemental） analysis and 1H NMR.The preliminary bioassay results indicate that compound 4a possesses certain fungicidal and herbicidal activities.In an attempt to search for novel compounds with agricultural bioactivity, a series of new polysubstituted pyridine derivatives, a- [ 2-methyl-5 -cyano-4- （ furan-2-yl） -3 -ethoxycarboxyl-pyridine-6-thio ] acetamide 4a, 2-methyl-5-cyano-4-（furan-2-yl）-3-acetyl pyridine-6-thioethers 5 and 6a were designed and synthesized by a three-step or one-step synthetic route. The structures of all the compounds prepared were confirmed by elemental analysis and ^1H NMR. The preliminary bioassay results indicate that compound 4a possesses certain fungicidal and herbicidal activities.

关 键 词：多取代吡啶 合成 生物活性 

分 类 号：O623.8[理学—有机化学]