大豆异黄酮对模拟失重雌性大鼠骨丢失的影响  

Effects of Soy Isoflavones on Bone Loss in Female Rats after Simulated Weightlessness

作　　者：付元华[1] 黄纪明[1] 朱德兵[1] 雷浪伟[1] 白树民[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2005年第6期419-421,共3页Space Medicine & Medical Engineering

基　　金：中国载人航天工程项目资助

摘　　要：目的研究大豆异黄酮对模拟失重雌性大鼠骨丢失的影响。方法24只雌性SD大鼠随机分为3组(每组8只),FC组:自由活动对照组(饲普通饲料);SC组:模拟失重对照组(饲普通饲料);SS组:模拟失重大豆异黄酮组(饲普通饲料+大豆异黄酮),实验期为21d。结果1)SC组大鼠股骨的骨密度(BMD)与生物力学参数最大载荷、弹性载荷、弹性能量吸收、最大应力及弹性应力的水平均显著低于FC组大鼠(P<0.05);而SS组大鼠股骨的BMD与生物力学参数最大载荷、弹性载荷、弹性能量吸收、最大应力及弹性应力的水平均显著高于SC组大鼠(P<0.05)。2)SC组大鼠血清中的碱性磷酸酶(AKP)、骨钙素(BGP)、雌二醇(E2)的水平均显著低于FC组,而血钙水平显著高于FC组(P<0.05);SS组大鼠血清中的AKP、BGP、E2的水平均显著高于SC组,而血钙显著低于SC组(P<0.05)。结论大豆异黄酮可以促进模拟失重雌性大鼠的骨形成,减少骨丢失,改善骨质量,这可能是大豆异黄酮的类雌激素作用所致。Objective To study the effects of soy isoflavones on bone loss in female rats after simulated weightlessness. Method Twenty four female SD rats were equally divided into 3 groups：one free control group（FC） and two simulated weightlessness groups （group SC and SS）. Rats in group FC and SC were fed with normal diet, while those in group SS were fed with diet supplemented with 0.1% （w/w） soy isoflavones. All rats drank pure water ad libitum. Result 1 ） In group SC rats, AKP,BGP and E2 content in serum, femur BMD, and biomechanical parameters （ maximum load, elastic load,elastic energy absorption, maximum stress and elastic stress）were significantly lower than those in group FC rats, whereas concentration of serum calcium was markedly higher than that in group FC rats. 2） In group SS rats, AKP,BGP and E2 content in serum, femur BMD,and biomechanical parameters were significantly higher than those in group SC rats, whereas concentration of serum calcium was markedly higher than that in group SC rats. Conclusion The results suggest that soy isoflavones can stimulate bone formation, decrease bone loss, and improve bone quality in female rats caused by simulated weightlessness. It may possiblely be related to the estrogen-like activity of soy isoflavones.

关 键 词：失重模拟 尾吊 大豆异黄酮 骨丢失 

分 类 号：R851.8[医药卫生—航空、航天与航海医学] R852.22[医药卫生—临床医学]