蒙古族人ACE基因和代谢综合征与高血压关系  

Relationship between ACE gene and metabolic syndrome and hypertension in Mongolian population

作　　者：王艳华[1] 佟伟军[2] 许群[3] 李永山[4] 方鸣武[3] 张永红[2] 邱长春[3] 乌正赉[5] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所呼吸道传染病室,北京102206 [2]苏州大学放射医学与公共卫生学院 [3]中国医学科学院中国协和医科大学基础所医学分子生物学国家重点实验室 [4]内蒙古通辽市科左后旗疾病预防控制中心 [5]中国医学科学院中国协和医科大学基础所流行病学教研室

出　　处：《中国公共卫生》2005年第12期1409-1411,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金项目(30271149);美国中华医学基金会项目(96-657)

摘　　要：目的探讨蒙古族人血管紧张素转换酶(ACE)基因多态性和高血脂、胰岛素抵抗与高血压的关系。方法在现况调查的基础上,分别对获得知情同意的450名高血压者和590名血压正常者采集血标本,进行血脂、血糖、胰岛素和ACE基因多态性的检测。结果高血压组的ID基因型频率显著高于血压正常组(P<0.05)。Ⅱ在ID基因型人群中,胰岛素敏感指数<-2.81与≥-2.81相比,OR值分别为2.23和1.94。结论蒙古族人群胰岛素敏感性低下可能是高血压的危险因素,且具有ID基因型者和胰岛素敏感性低下之间可能产生协同作用。Objective To explore association of polymorphism of ACE gene with high lipid and insulin resistance on hypertension in Mongolian population. Methods On basis of a cross sectional study, 450 hypertensives and 590 nomotensives were recruited as the subjects to test blood lipid, blood sugar, insulin and polymorphism of ACE gene. Results Frequency of genotype ID in hypertensives was significandy higher than that in nomotensives（P〈0.05）. In populations with genotype Ⅱ and ID, odds ratio（ OR ）of group with ISI 〈 - 2.81 to group with ISI≥- 2.81 for hypertension were 2.23 and 1.94, respectively. Conclusion The Mongolian population with low insulin sentivity could increase their risk for hypertension, and further, genotype ID plus insulin resistance would exert a synergetic effect on hypertension.

关 键 词：高血压 ACE基因多态性 高血脂 胰岛素抵抗 

分 类 号：R181.37[医药卫生—流行病学]