气管炎菌苗佐治反复呼吸道感染的临床疗效及免疫功能变化的观察  

The clinical and immune effect observation of trachitis vaccine on repeatedly respiratory infection

作　　者：鲍非 

机构地区：[1]娄底市中心医院儿科,417000

出　　处：《国外医学（呼吸系统分册）》2005年第11期808-809,共2页Section of Respiratory System Foreign Medical Sciences

摘　　要：目的探讨气管炎菌苗佐治反复呼吸道感染(RRI)的临床疗效与免疫功能变化。方法设气管炎菌苗佐治组(n=98)及常规治疗组(n=96)。比较两组患儿治疗后的临床疗效,同时检测治疗前后免疫抗体、T细胞亚群和IFN-γ水平的变化。结果气管炎菌苗佐治组较治疗前IgA、IgG均明显升高,P均<0.05,T细胞亚群CD3+、CD4+均明显升高,CD8+明显下降,P均<0.01,IFN-γ水平升高非常明显,P<0.01。常规治疗组以上指标治疗前后无明显变化。结论气管炎菌苗可通过增强免疫功能来提高RRI临床疗效以及预防效果。Objective To investigate the clinical and immune function change of trachitis vaccine treating repeatedly respiratory infeetion（RRI）, Methods There was both trachitis vaccine group（n= 98） and routine treatment group（n= 98）. The clinical effect was compared between two groups after treatment. Meanwhile the immune antibody, T cell subgroup and IFN-γ were detected before and after treatment. Results Compared with treatment before,IgA,IgG increased remarkedly, P〈0.05,T cell subgroup CD^＋3 , CD^＋4 increased remarkedly,CD^＋8 decreased remarkedly in trachitis vaccine group, P〈0.05. There was no difference before and after treatment in routine group. Conclusions Trachitis vaccine could enhance immune function to improve clinically therapeutic and prophylactic effect of RRI.

关 键 词：气管炎菌苗 免疫 呼吸道感染 

分 类 号：R725.6[医药卫生—儿科] R979.5[医药卫生—临床医学]