病理性瘢痕组织中Ki-67的表达  

Expression of Ki-67 in abnormal scar

作　　者：康深松[1] 陈言汤[2] 牛扶幼[2] 刘林嶓[2] 

机构地区：[1]河南省人民医院整形外科,郑州450003 [2]郑州大学第一附属医院整形外科,郑州450052

出　　处：《郑州大学学报（医学版）》2005年第6期1140-1141,共2页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:了解病理性瘢痕组织中Ki67的表达,探索瘢痕增生的机制。方法:应用免疫组化SABC法检测60例病理性瘢痕(包括增生性瘢痕和瘢痕疙瘩)、15例正常皮肤(取自病理性瘢痕患者自身)及15例非病理性瘢痕组织中Ki67蛋白的表达。结果:Ki67呈核表达。病理性瘢痕组织中Ki67标记指数(5.35±1.92)显著高于非病理性瘢痕和正常皮肤组织(0.41±0.33,0.33±0.34,P<0.05)。结论:瘢痕增生可能为瘢痕成纤维细胞增殖活性增高所致。Aim ： To explore the expression of Ki-67 in the abnormal scar and the role it plays in abnormal scar formation. Methods ： The expression of Ki-67 was detected using immunohistochemical SABC method in 60 specimens of abnormal scar, 15 specimens of normal skin and 15 specimens of normotrophie scar. Results ： The expression of Ki-67 was localized in the nuclei. Ki-67 labelling index in abnormal scar （5. 35±1.92） was higher than those in normotrophic scar （0.41±0.33 ） and normal skin （ 0.33±0.34 ） , respectively （ P 〈 0.05 ）. Conclusion ： The formation of abnormal scar could be the result of highly proliferative activity of fibroblasts.

关 键 词：增生性瘢痕 瘢痕疙瘩 KI-67 

分 类 号：R619.6[医药卫生—外科学]