参麦注射液对大鼠肾缺血再灌注损伤中SOD、MDA作用的研究  

Resisting the Oxidation of Shen mai Injection on Renal Ischemia/Reperfusion Injuries in Rats

作　　者：林明佳[1] 何小洪[1] 谢利英[1] 莫蝶仪[1] 何振丹[1] 关健明[1] 董晓先[2] 

机构地区：[1]广州医学院临床一系2003级6班 [2]广州医学院病理生理学教研室,广东广州510182

出　　处：《河南职工医学院学报》2005年第5期266-267,共2页Journal of Henan Medical College For Staff and Workers

摘　　要：目的探讨参麦注射液在大鼠肾缺血-再灌注损伤中的抗氧化作用。方法通过建立大鼠急性肾再灌注损伤模型,测定参麦注射液对肾缺血-再灌注后肾组织SOD活力与MDA含量的变化。结果与对照组相比,使用参麦注射液后,在再灌注0 h1、h1、2 h及24 h后肾组织SOD活力明显升高(P值分别<0.01,0.05,0.01),MDA含量明显降低(P值分别<0.05,0.01,0.05)。结论参麦注射液在大鼠肾缺血-再灌注损伤模型中,有抗自由基损伤和减轻脂质过氧化的作用。Objective To study the anti-oxidant effects of shenmai injection on rats with renal ischemia repeffusion injuries. Methods Shenmai injection was administered intrapertioneally in rats for every 6 hours from 2 days before the ischemia until 0,1,12,24 hours after reperfusion. Results SOD, MDA were significantly higher （ P 〈 0.01 P 〈 0.05 P 〈 0.01 respectively）, while the concentration of MDA was significantly lower （ P 〈 0.05 P 〈 0.01 P 〈 0.05 respectively）. Conclusion Shenmai injection may have anti-oxidative properties against renal ischemia reperfusion injuries in rats, possibly by alleviating the damages caused by free radicals and lipid peroxidation.

关 键 词：参麦注射液 大鼠 肾 缺血-再灌注损伤 

分 类 号：R322.61[医药卫生—人体解剖和组织胚胎学]