血脉通颗粒对家兔动脉粥样硬化形成的干预作用机理研究  

Mechanism study of Xuemaitong Granules on interposing effect to atheroscleorsis in rabbits

作　　者：张琪[1] 曾晓辉[1] 刘产明[1] 

机构地区：[1]常州市中医医院,江苏常州213003

出　　处：《甘肃中医学院学报》2005年第6期18-23,共6页Journal of Gansu College of Traditional Chinese Medicine

基　　金：江苏省中医药管理局资助项目(9970)

摘　　要：目的:探索血脉通颗粒对家兔颈动脉粥样硬化斑块形成的干预作用机理。方法:高脂饲料加空气干燥术形成家兔颈动脉粥样硬化模型,并给予血脉通颗粒治疗3个月后,观察各组家兔血清循环内皮细胞(CEC)、血清基质金属蛋白酶(MMP-1、MMP-9)及金属蛋白酶组织抑制剂(TIMP-1)、血清内皮素(ET)、一氧化氮(NO)、血浆cGMP、血管紧张素(AngⅡ)及血液黏度、超氧化物歧化酶(SOD)、丙二醛(MDA)的变化。结果:血脉通颗粒可降低造模家兔血清CEC、MMP-1、MMP-9、MDA及ET,升高TIMP-1、cGMP、AngⅡ、SOD及NO水平,改善造模家兔血液流变学指标。结论:血脉通颗粒可通过干预高血脂对血管内皮细胞的损伤、抑制血清MMP-1和MMP-9活性、干预高脂饲料喂食所造成血浆cGMP和AngⅡ水平下降、抗氧化及改变血液流变学等多途径、多环节、多靶点地干预颈动脉斑块形成。Objective ：To explore the mechanism of Xuemaitong Granules on interposing effect to atheroscleorsis in rabbits. Methods： Crotid atherosclerotic model of rabbit were induced by high cholesterol diet and air drying operation and had been treated with Xuemaitong Granules for 3 monthes. Then observed CEC, MMP-1, MMP-9, TIMP-1, ET, NO, cGMP, AngⅡ and blood viscosity, SOD, MDA. Results ： Xuemaitong Granules could decrease the levels of CEC, MMP-1, MMP-9, MDA and ET, and increase the level of TIMP-1, cGMP, AngⅡ, SOD and NO in rabbits, improve blood rheology. Conclusion ： Xuemaitong Granules can interpose atheroscleorsis through many ways,links and targets.

关 键 词：动脉粥样硬化 循环内皮细胞 基质蛋白酶 一氧化氮 CGMP 血管紧张素 血脉通颗粒 

分 类 号：R285.5[医药卫生—中药学]