“咳喘宁”贴膏皮肤用药毒性实验研究  被引量:1

Experimental study on acute toxicity of Kechuanning Adhesive Plaster to skin

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作  者:王晶[1] 关东升[1] 陈淑彦[1] 司小兵[1] 刘世琼 

机构地区:[1]甘肃中医学院,甘肃兰州730000

出  处:《甘肃中医学院学报》2005年第6期32-35,共4页Journal of Gansu College of Traditional Chinese Medicine

摘  要:目的:探讨“咳喘宁”贴膏皮肤用药的安全性。方法:通过对健康家兔皮肤急性毒性试验、健康豚鼠皮肤刺激性试验及皮肤过敏性试验,观察“咳喘宁”贴膏对动物经皮肤用药的急毒、刺激和过敏性。结果:“咳喘宁”贴膏对家兔完整皮肤和破损皮肤未引起急性毒性反应;对豚鼠完整皮肤和破损皮肤有轻度刺激性,但给药后48 h,这种刺激性消失;对豚鼠完整皮肤无致敏作用。结论:“咳喘宁”贴膏临床用药安全、无毒。Objective :To explore the reliability of Kechuanning Adhesive Plaster to skin. Methods:Through acute toxicity test to health rabbits, and irritable and hypersensitive test to health guinea pig, observed the acute toxicity,irritation and hypersensitivity of Kechuanning Adhesive Plaster to animal skin. Resuhs:Kechuanning Adhesive Plaster was not cause acute toxicity reaction to integrated and worn skin of rabbits, and had little irritation to guinea pig and hadn' t hypersensitivity to integrated skin of guinea pig. But feeding drugs latter 48 hours, the irritation disappeared. Conclusion:Kechuanning Adhesive Plaster has lower toxicity and well reliability in clinic.

关 键 词:“咳喘宁”贴膏 急性毒性 皮肤刺激性 皮肤过敏性 

分 类 号:R285.5[医药卫生—中药学]

 

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