乙型肝炎病毒前C基因突变及其临床意义  

The study of mutation in pre-C region of hepatitis B virus DNA and its clinical significance

作　　者：薛晓华[1] 任中原[1] 

机构地区：[1]天津医科大学微生物学教研室,300070

出　　处：《中华实验和临床病毒学杂志》1996年第2期124-127,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：分析21例慢性乙型肝炎患者血清乙型肝炎病毒(HBV)DNA 前 C 区序列,发现16例抗—HBe 阳性血清中9例发生前 C 区第1896位 G→A点突变,产生一个终止密码,而5例 HBeAg 阳性血清均未发生变异。比较抗-HBe 阳性者中突变株与野生株感染的丙氨酸转氨酶(ALT)值,二者具有显著性差异(P<0.05)。在突变组中亦有3例 ALT 值正常或稍高于正常。Direct sequencing of the pre-C region of hepatitis B virus revealed in 9 of 16 anti-HBe positive chronic carriers a HBV strain with a point mutation from G to A at nucleotide 1896 creating a stop codon.No mutation was observed in HBeAg postitive patients.ALT levels were significantly higher in patients infected with the pre-C mutant compared with patients who had a wild-type strain(P<0.05).However,three patients infected with pre-C mutant also had normal or slightly elevated ALT levels.

关 键 词：乙型肝炎病毒 DNA病毒 抗-HBE 基因 

分 类 号：R512.620.2[医药卫生—内科学]