急慢性丙型肝炎患者病毒血症与抗体反应及肝损害的关系分析  

Detection of hepatitis C virus RNA with regard to antibody response and to biochemical markers of liver injury in the acute and chronic hepatitis C

作　　者：张常然 宁宜云[2] 谢支度 骆名其[2] 

机构地区：[1]湖北省宜昌市传染病医院,宜昌443003 [2]湖北医科大学附属第二医院

出　　处：《中华实验和临床病毒学杂志》1996年第2期149-151,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：对19例急性和20例慢性丙型肝炎患者的血清丙型肝炎病毒(HCV)RNA、丙型肝炎病毒抗体(抗-HCV)和肝损害指标丙氨酸转氨酶(ALT)、血清总胆红素(TB)进行了检测。在19例急性丙型肝炎发病初期,HCV-RNA 阳性19例(100.0%),抗-HCV 阳性11例(57.9%);20例慢性丙型肝炎患者中,HCV-RNA 阳性17例(85.0%),抗-HCV 阳性17例(85.0%)。急性丙型肝炎发病初期的 ALT 明显升高(P<0.05)。3个月后对10例急性和10例慢性丙型肝炎患者的血清 HCV-RNA、抗-HCV、ALT 和TB 进行了复测,急、慢性丙型肝炎的上述指标均无显著性差异。表明 HCV-RNA 较抗-HCV 更能全面反映 HCV 感染的实际情况,并有助于丙型肝炎的早期诊断。Hepatitis C virus(HCV)RNA by reverse tanscriptase polymerase chain reaction(RT-PCR),antibody to hepatitis C virus(anti-HCV)by ELISA and biochemical markers of liver injury(ALT and TB)were investigated in 19 patients with acute hepatitis C and 20 patients with chronic hepatitis C infection.In 19 acute hepatitis C patients at the clinical onset,19 cases(100%)and 11 cases(57.9%)were positive for HCV-RNA and anti-HCV respectively.In 20 chronic hepatitis C patients,17 cases(85.0%)were positive for HCV-RNA and 17(85.0%)for anti-HCV.The level of ALT was higher in acute hepatitis C patients than that in chronic patients(P<0.05).After three months, there was no significant difference in HCV-RNA,anti-HCV and the level of ALT respectively(P>0.05)between 10 cases of acute hepatitis C and 10 cases of chronic hepatitis C.These results indicated that hepatitis C virus RNA detec- tion might provide important information as compared with anti-HCV marker in early diagnosis.

关 键 词：聚合酶链反应 丙型肝炎病毒 病毒抗体 

分 类 号：R512.63[医药卫生—内科学]