膦酰基甲酸在抗单纯疱疹病毒感染小鼠动物模型上的作用  

Effect of foscarnet on experimental mouse model infected by acyiovir-resistant herpes simplex virus type 2

作　　者：李玉雨[1] 金今福[1] 皆川洋子 田中真二 森良一 

机构地区：[1]吉林省延边医学院,延吉133000 [2]日本九州大学医学部ゥィルメ学教室

出　　处：《中华实验和临床病毒学杂志》1996年第2期182-187,共6页Chinese Journal of Experimental and Clinical Virology

摘　　要：将单纯疱疹病毒(HSV)RK(胸腺核苷促化酶变异的抗无环鸟苷株)和亲代8620K 接种小鼠腹腔,观察病毒播散及死亡率。结果50%致死量(LD50)和 HSV 往各脏器的播散,两者间无显著性差异;非经口法治疗 ACV 对8620K 感染有效,但对 RK 则无效;PFA 非经口法治疗不仅对 RK 和8620K感染均有效,而且还抑制对肝脏、脊髓和脑内病毒的播散,经口投入可以抑制病毒在肝脏内复制。Foscarnet(PFA)is a viral DNA polymerase inhibitor and has been used in the treatment of acyclovir- resistant herpes simplex virus(HSV)infection,but the study of PFA in the infected animals is fairly less than that of acyclovir(ACV),and the mechanism of HSV spread in the infected animals is not clear yet.We studied the virus spread and mortality following intraperitoneal inoculation of HSV-2 RK(an acylovir-resistant recombinant virus with altered thymidine kinase activity)while comparing to its parent virus 8620K.Neither the 50% lethal dose(LD50)nor the average survival time was significantly different between the two virus strains.Parenteral ACV treatment-vzas found to be effective against 8620K but not RK infection.Parenteral PFA treatment was effective against both RK and 8620K,and also inhibited spread of either virus to the liver,the spinal cord and the brain.Peroral PFA administration was found to prevent the virus replication in the liver.

关 键 词：无环鸟苷 膦酰基甲酸 单纯疱疹病毒 抗药性 

分 类 号：R752.11[医药卫生—皮肤病学与性病学]