自发性高血压大鼠心肌间质胶原的改建及培哚普利的作用  

Remodeling of Cardiac Interstitium Collagen and The Effect of Perindopril in Spontaneously Hypertensive Rats

作　　者：孙旗[1] 张寄南[1] 杨国平[1] 苄志平 杨迪 马文珠[1] 王敬良[1] 

机构地区：[1]南京医科大学附属第一医院心血管病研究所,210029

出　　处：《高血压杂志》1996年第2期95-99,共5页Chinese Journal of Hypertension

摘　　要：目的应用图像分析系统和透射电镜技术研究自发性高血压大鼠(SHR)心肌间质的改建及转换酶抑制剂培哚普利的影响。方法 SHR 治疗组给予培哚普利2mg/kg·d^(-1),共12周。结果 SHR 对照组肌内膜和肌外膜胶原含量比 WKY 组增多(P<0.01)。SHR 治疗组左室重量明显低于 SHR 对照组且胶原含量明显下降(P<0.01)。电镜下,SHR 对照组心肌细胞间隙内充满胶原纤维,在某些区域还见有胶原原纤维中断、排列紊乱。SHR 治疗组未见上述改变。结论心肌间质胶原直接参与了高血压性心肌肥厚。培哚普利能逆转高血压动物心肌肥厚并防止心肌间质纤维化。Aim Investigate the remodeling of cardiac interstitium collagen and the effect of perindo- pril in spontaniously hypertensive rats(SHR). Methods Animals were randomized into three groups.The treated SHR group received converting enzyme inhibitor(perindopril 2mg/kg daily)during 12 weeks.The pathology of cardiac interstitium col- lagen were studied with image analyser system(IAS) and electron microscopy.Results The collagen contents from endomyocardium and epimyocardium was markedly increased in the untreated SHR group compared to WKY group(P<0.01).The left ven- tricular weight and collagen contents were significant- ly decreased in the treated SHR group compared to untreated SHR group(P<0.01).Observed by elec- tron microscope,cardiac interstitium wes filled with fibrillar collagen in the untreated SHR group.Break and disarrangement in fibrillar collagan were also found in some field.These changes were not found in the treated SHR group.Conclusion The collagen in cardiac interstitium directly participated in myocar- dial hypertrophy.Perindopril induced reversion of the left ventricular hypertrophy and prevented fibrosis of cardiac interstitium.

关 键 词：自发性 高血压 大鼠 心肌肥厚 培哚普利 

分 类 号：R544.105[医药卫生—心血管疾病]