2-(4-吡啶基)-5-芳基-1,3,4-噁二唑的合成与表征  

Synthesis and Characterization of 2-(4-Pyridyl)-5-aryl-1,3,4-oxadiazoles

作　　者：李德江[1] 张吉斌[1] 付和清[2] 

机构地区：[1]郧阳师范高等专科学校化学系,湖北丹江口442700 [2]华南理工大学化工学院化工研究所,广东广州510640

出　　处：《合成化学》2005年第6期569-571,576,共4页Chinese Journal of Synthetic Chemistry

基　　金：湖北省教育厅2004年科学技术研究资助项目(2004D001)

摘　　要：以碳酸钠为缚酸剂,4-吡啶甲酰肼与苯甲酰氯反应得N,N′-二酰基肼,后者在POC l3作用下脱水环化成2-(4-吡啶基)-5-芳基-1,3,4-噁二唑,其结构经1H NMR,IR,MS和元素分析确认,并对其裂解途径进行了探讨。Seven novel 2- （4-pyridyl） -5-aryl-1,3,4-oxadiazoles were synthesized by cyclization of N, N＇-diacylhydrazines（2） with POCI3. 2 were obtained from 4-nicotinic hydrazine reacted with aroyl chloride using Na2CO3 as acid acceptor for 6 h - 7 h. The structures were characterized by ^1H NMR, IR, MS and elemental analysis, and fragmentation mechanism of MS spectra was discussed as well.

关 键 词：噁二唑 二酰基肼 合成 表征 

分 类 号：O626.24[理学—有机化学] TQ251.1[理学—化学]