4-羟基联苯-4′-甲酸-L-2-甲基丁醇酯的合成  

Synthesis of L-2-methylbutyl-4-hydroxylbiphenyl-4′-carbonylate

作　　者：沈金平[1] 章于川[1] 范程士[1] 杭德余[1] 吴兵[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《合成化学》2005年第6期614-617,共4页Chinese Journal of Synthetic Chemistry

基　　金：安徽省"十五"攻关资助项目(200183)

摘　　要：以4-羟基联苯,4-羟基-4′-氰基联苯和手性L-2-甲基丁醇为原料,通过三条路线合成了铁电性液晶中间体4-羟基联苯-4′-甲酸-L-2-甲基丁醇酯。5步法(醚化、酰化、溴仿、水解和酯化)总收率35.6%;3步法(酰化、溴仿和酯化)总收率50.7%;而以4-羟基-4′-氰基联苯为原料的一步合成法收率64.4%。中间体和目标产物的结构经1H NMR和IR确证。L-2-methylbutyl-4-hydroxylbiphenyl-4＇-carbonylate was synthesized from 4-hydroxylbiphenyl, 4-hydroxyl-4＇-cyanobiphenyl and chiral alcohol L-2-methylhutanol by three synthesis routes. The total yield was 35.6% by five-step method （etherification, F - C acylation, haloform-reaction, hydrolysis and esterification）. The total yield was 50.7% by three-step method（ F - C acylation, haloform-reaction and esterification） . The yield by one step method was 64.4%. The structures were confirmed by ^1H NMR and IR.

关 键 词：铁电性液晶 联苯 合成 

分 类 号：O623.624[理学—有机化学] O621.3[理学—化学]