盐酸罗沙替丁乙酸酯的合成  

Synthesis of Roxatidine Acetate Hydrochloride

作　　者：张爱华[1] 沈义鹏[1] 

机构地区：[1]江苏省药物研究所,江苏南京210009

出　　处：《中国医药工业杂志》2005年第12期732-733,共2页Chinese Journal of Pharmaceuticals

摘　　要：间羟基苯甲醛和哌啶缩合得到的3-(1-哌啶甲基)苯酚,与3-氯丙胺在DMF中于90～95℃直接缩合制得3-(3-(1-哌啶基甲基)苯氧基)丙胺,再依次和氯乙酰氯和乙酸钾经缩合反应得到抗溃疡药盐酸罗沙替丁乙酸酯,总收率59%。Roxatidine was synthesized from 3-（piperidin-l-ylmethyl）phenol by condensation with 3-chloropropylamine in DMF at 90-95℃ to give 3- [ （3-piperidin-1-ylmethyl） phenoxy] propylamine followed by successive reactions with chloroacetyl chloride and potassium acetate in 59 % overall yield.

关 键 词：罗沙替丁 抗溃疡药 组胺H2- 受体阻滞剂 合成 

分 类 号：R975.6[医药卫生—药品]