胰岛素脂质体的制备及在电致孔下的经皮渗透  

Preparation and Transdermal Delivery by Electroporation of Insulin Liposomes

作　　者：戚明[1] 蒋国强[1] 丁富新[1] 

机构地区：[1]清华大学化工系,北京100084

出　　处：《中国医药工业杂志》2005年第12期751-753,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金(20376038)

摘　　要：采用反相蒸发法制备了平均粒径122.7nm的胰岛素脂质体,并考察了电致孔经皮转运情况。结果表明,在电致孔条件下,胰岛素脂质体2h累积渗透量是载药脂质体被动扩散的1倍;是原药及其与空白脂质体混合物的2～3倍。The insulin liposomes with average diameter of 122.7nm were prepared by phase evaporation method. The transdermal delivery by electroporation of insulin liposomes was investigated. The results showed that under the electroporation condition, the 2h accumulative penetration amount of insulin liposomes was double the amount of passive diffusion and 2 - 3-fold increase than the bulk and also the mixture of bulk and blank liposomes.

关 键 词：胰岛素 脂质体 经皮给药 电致孔 

分 类 号：R944.9[医药卫生—药剂学] R975.15[医药卫生—药学]