青蒿琥酯治疗小儿脑型疟疾的临床分析  

A clinical evaluation of administration of artesunate in treatment of cerebral malaria in 65 cases

作　　者：陈翔[1] 刘丽[1] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2005年第12期836-837,共2页Ningxia Medical Journal

摘　　要：目的为了解青蒿琥酯治疗脑型疟疾的疗效。方法用青蒿琥酯与传统的奎宁作对比,观察5天后的疗效。结果治疗组65例患儿,总有效率为98.5%,对照组63例患儿,总有效率73.0%,两组比较有显著性差异。治疗组的疟原虫转阴率明显高于对照组(P<0.01),临床症状改善差异明显,对照组的副作用相对较大。结论青蒿琥酯治疗脑型疟疾疗效好而迅速,副作用少,可以作为首选药。Objective To evaluate the therapeutic effect of Artesunate in cerebral malaria treatment. Methods Artesunate and quinine were administrated in two groups of patient with cerebral malaria. The effect was evaluated after 5 days of administration. Results Artesunate was effective in 64 of 65 （98.5 % ） cases while the effective rate is 73.0 % in control group, in which quinine was administrated. The difference is significant. The disappearance rate of plasmoditium is much higher in Artesunate group（ P 〈 0.01 ）. Besides, the side effect of drug is much lower and the improvement of clinical symptoms is much better in Artesunate group than that in control gro. Conclusion Artesunate works better, faster, and has less side effect than quinine in treatment of cerebral malaria. It can be the first choice in such case.

关 键 词：青蒿琥酯 脑型疟疾 疗效 

分 类 号：R725.3[医药卫生—儿科]