沙美特罗干粉吸入剂治疗哮喘的临床研究  

A RANDOMIZED CROSS OVER COMPARATIVE STUDY ON THE EFFICACY OF SALMETEROL IN TREATMENT OF ASTHMA

作　　者：孙铁英[1] 夏小红 缪竞智[1] 张桂兰[1] 

机构地区：[1]北京医院呼吸内科

出　　处：《中国新药杂志》1996年第4期281-282,共2页Chinese Journal of New Drugs

摘　　要：随机、交叉、双盲观察沙美特罗对３０对哮喘患者的疗效，２次／ｄ，结果：两组临床症状计分明显下降（Ｐ＜０．０５），但沙美特罗组起效慢，对夜间症状效果佳，优于沙丁胺醇。两组ＦＥＶ１和ＦＥＶ１．０％比治疗前明显提高（Ｐ＜０．０１，Ｐ＜０．０５）；ＰＥＦＲ也明显增加（Ｐ＜０．０１，Ｐ＜０．０５）。沙美特罗组晚上ＰＥＦＲ增加明显，缩小了日间变异。两组均未出现血压、心率和体重的显著变化，未见心慌、手抖及肝肾功能等异常。结果表明，沙美特罗能缓解症状，改善肺功能，但起效慢，不适合急诊缓解症状用。pairs of patient with mild to moderate asthma were randomized to receive salmeterol 50 μg bid or salbutamol 400 μg qid in a cross over fashion.Results showed that both morning and evening peak expiratory flow rates(PEFR)are increased and diurnal and nocturnal symptoms are improved( P<0.01 ).The improvement in docturnal symptoms and evening PEFR for salmeterol was statistically significant in comparation with salbutamol.No any ADRs were observed.Therefore,it can be suggested that salmeterol is more effective for nocturnal asthma,but it must not be used in acute atack of asthma.

关 键 词：哮喘 沙美特罗 治疗 

分 类 号：R562.250.5[医药卫生—呼吸系统]