小儿静脉穿刺消毒液的制备及质量控制  

Preparation and Quality Control of Disinfectant for Venepuncture in Children

作　　者：惠培业[1] 刘梅和[1] 魏文华[1] 赵红[1] 付爱芬[1] 刘峰[1] 

机构地区：[1]山东潍坊市妇幼保健院,潍坊市261011

出　　处：《中国药房》2005年第23期1790-1791,共2页China Pharmacy

摘　　要：目的:制备小儿静脉穿刺消毒液并建立其质量控制方法.方法:以消旋山莨菪碱、烟酸为主药,以75%乙醇为溶剂,配制小儿静脉穿刺消毒液;采用非水滴定法、紫外分光光度法分别测定消旋山莨菪碱、烟酸的含量.结果:消旋山莨菪碱、烟酸平均回收率分别为99.96%(RSD=0.04%)、100.04%(RSD=0.16%),标示量均在98.87%～100.8%内.结论:本方法快速、简便、分辨率高、结果准确,适用于该制剂的质量控制.OBJECTIVE： To prepare the disinfectant for venepuncture in children and to establish the quality control for this preparation. METHODS： Nicotinic acid and racanisodamine were taken as the chief components for the preparation of this disinfectant, 75% alcohol as the solvent. Nicotinic acid were determined by ultraviolet and visible spectrophotometry（UVVis）; raeanisodamine were determined by nonaqueous titrations. RESULTS： The average recoveries of racanisodamine and nicotinic acid were 99.96% （RSD- 0.04%） and 100.04% （RSD = 0.16% ） respectively, which all were in the range of 98.87% 100.8%. CONCLUSION： The disinfectant produced with the established method is simple in preparation, accurate in content determination, stable and reliable in quality.

关 键 词：消旋山莨菪碱 烟酸 月桂氯革酮 制备 质量控制 

分 类 号：R979.7[医药卫生—药品] R927.2[医药卫生—药学]