碱性成纤维细胞生长因子(bFGF)促进鼻部粘膜修复的临床研究  

Clinical research of bFGF on wound healing of nasal mucosa

作　　者：何刚[1] 敖敏[1] 杜泽秀[1] 

机构地区：[1]四川省医学科学院.四川省人民医院,四川成都610072

出　　处：《四川医学》2005年第12期1368-1369,共2页Sichuan Medical Journal

摘　　要：目的观察碱性成纤维细胞生长因子(bFGF)在鼻粘膜创面应用的治疗效果。方法鼻粘膜创面用bFGF换药的治疗组30例,与鼻粘膜创面用传统方法换药的对照组30例,从修复天数和粘膜修复情况进行比较。结果bFGF治疗组粘膜修复平均天数(1.93±0.64)d短于传统换药对照组(7.37±2.24)d,t检验(t=12.95,P<0.001)。治疗组治愈率(100%)高于对照组(80%),卡方检验(χ2=6.67,P<0.05)。结论bFGF能明显促进粘膜创面愈合,明显缩短修复时间。Objective To evaluate the effect of bFGF in treating wounds of nasal mucosa. Methods 60 patients were divided randomly into bFGF group and tranditional therapy group （as control）. Results Comparison between the efficiency of the two groups revealed that bFGF had good healing effect. Wound healing time in bFGF group was significantly shorter than that in control group（P〈0.001）. Healing rate of bFGF group was stronger than that of control group（P〈0.05）. Conclusion bFGF treatment is superior to traditional therapy in treating wounds of nasal mucosa.

关 键 词：碱性成纤维细胞生长因子 粘膜 创面 修复 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]