趋化因子拮抗剂Met-RANTES延缓移植物排斥反应研究  

Study on the Effects of Chemokine Antagonist Met-RANTES on Graft Rejection

作　　者：孙志成[1] 郑红[2] 李世荣[2] 吴军[2] 

机构地区：[1]武警医学院附属医院(平津医院)整形美容中心,天津300162 [2]第三军医大学西南医院烧伤研究所

出　　处：《天津医药》2005年第12期780-782,共3页Tianjin Medical Journal

基　　金：国家自然科学基金资助课题(项目编号:第30170900号)

摘　　要：目的:探讨趋化因子拮抗剂Met-RANTES对内皮细胞与异体T细胞趋化、黏附作用的影响。方法:采用T细胞与血管内皮细胞混合培养的方法,观察使用趋化因子拮抗剂Met-RANTES干预前后内皮细胞趋化因子的表达,以及血管内皮细胞对T细胞趋化、黏附率的变化。结果:血管内皮细胞与T细胞混合培养可见内皮细胞表达的趋化因子RANTES、MCP-1及MIP-1α,RANTES的表达率增高。趋化因子拮抗剂Met-RANTES可以显著减低内皮细胞对T细胞的趋化和黏附。结论:趋化因子拮抗剂Met-RANTES通过减低内皮细胞与异体T细胞的趋化与黏附而发挥其作用。Objective： To study the effects of chemokine antagonist Met-RANTES on endothelium adhesion and chemotaxis to T lymphocyte. Methods： Endothelium chemokine expression and adhesion and chemotaxis of endothelium to T lymphocyte were observed before and after Met-RANTES intervention by endothelium and T cell mixed culture. Results： Endothelium expressed RANTES, MCP-1 and MIP-1α were observed by endothelium and T cell mixed culture, and the expression of RANTES increased. Endothelium adhesion and chemotaxis to T lymphocyte were decreased by chemokine antagonist Met- RANTES. Conclusion： Chemokine antagonist Met-RANTES plays an important role in decreasing endothelium adhesion and chemotaxis to T lymphocyte.

关 键 词：RANTES 内皮细胞 T淋巴细胞 

分 类 号：R971.1[医药卫生—药品] R562.25[医药卫生—药学]