下丘脑室旁核与中缝大核在下行痛觉调制中作用的研究  

DESCENDING MODULATION EFFECT OF PVN AND NRM ON PAIN TRANSMISSION

作　　者：崔存德 张慧 张爱军 

出　　处：《滨州医学院学报》1996年第2期105-108,共4页Journal of Binzhou Medical University

摘　　要：用４％水合氯醛麻醉大鼠，在下丘脑室旁核（ＰＶＮ）、中缝大核（ＮＲＭ）埋藏双极刺激电极或不锈钢管，以便刺激、电解损毁或微电泳兴奋剂或激动剂。并暴露脊髓背角，利用玻璃微电极记录脊髓背角神经元对伤害刺激坐骨神经的反应，信号经计算机处理。实验结果表明：电刺激ＰＶＮ可抑制脊髓背角神经元伤害反应，其作用时间持续１５～２５ｍｉｎ，刺激ＰＶＮ后３ｍｉｎ抑制作用最强（Ｐ＜０．０１）。电解损毁ＮＲＭ后，刺激ＰＶＮ抑制脊髓背角神经元伤害反应仍然存在，并符合ＰＶＮ抑制伤害反应的林点，实验结果提示：ＰＶＮ参与脊髓背角神经元伤害反应的调制过程，其作用可通过内源性镇痛系统（ＰＡＧ－ＮＲＭ）途径，但也可通过ＰＶＮ－脊髓背角间的直接神经投射途径。Experiments were performed on rats anesthetized with 4% chloral hydrate. Dipolar stimulating electrodes or stainless steel pipettes were buried in hypothalamic paraventricularis nuclei(PVN) and nucleus raphe magnus(NRM) to present stimulation, dysfunction or electrophoresis of excitants or agonists, while glass microelectrodes were used to record the response of the dorsal horn neuron of spinal cord to nociceptive stimulation of the sciatic nerve. The data were sampled and processed by a computer. The result showed electric stimulation of PVN could inhibit the nociceptive response of the spinal cord dorsal horn neurons. The effect lasted 20 minutes,the peak being at 3 min after the stimulation(P<0. 001). After damaging NRM electrolytically stimulation of PVN could also inhibit the nociceptive response of dorsal horn neurons, which was in line with the characteristic of inhibitory effect of PVN on nociceptive response. The result indicates PVN may participate in the modulation of nociceptive response of spinal cord dorsal horn neurons,and it plays its role not only via the pathway of intrinsic analgesic system(PAG-NRM), but by way of its direct fiber projection to spinal cord dorsal horn as well.

关 键 词：下丘脑室旁核 痛觉调制 中缝大核 刺激电极 

分 类 号：R338.27[医药卫生—人体生理学]